PMID: 9450677Feb 5, 1998Paper

Temporal variability of jun family transcription factor levels in peripherally or centrally transected adult rat dorsal root ganglia

Brain Research. Molecular Brain Research
A M Kenney, J D Kocsis

Abstract

Enhanced chemiluminescent (ECL) immunoblotting was used to quantitatively assess the initial changes in jun family transcription factor protein levels in adult rat lumbar dorsal root ganglia (DRG) after peripheral axotomy and dorsal root transection, and to study the effects of neurotrophic factor administration on these changes. Transection of central (dorsal root) or peripheral (spinal nerve) branches of DRG neurons resulted in rapid elevation of c-jun protein levels, which was transient after dorsal root transection but sustained, though slightly attenuated, after spinal nerve transection. These results suggest that injury-induced c-jun elevation is biphasic, consisting of an early, transient, injury-initiated phase and a more prolonged secondary phase specific to peripheral target disconnection. c-jun protein changes were not modulated by administration of NGF or BDNF. Immunohistochemistry was used to localize c-jun protein induction to DRG neurons. Using ECL immunoblotting, we also observed temporally regulated increases in junD protein levels after both injuries. A transient up-regulation of junB was detected by immunoblotting 5 days after peripheral axotomy, coincident with a slight decrease in c-jun protein levels.

References

Aug 1, 1977·Journal of Neurochemistry·M A Bisby, V T Bulger
Jan 13, 1978·Brain Research·Y Komiya, M Kurokawa
Oct 1, 1992·Trends in Biochemical Sciences·M Karin, T Smeal
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K RyderD Nathans
Dec 1, 1972·The Journal of Physiology·S Ochs
Sep 29, 1970·Brain Research·B G Cragg
Jan 1, 1971·International Review of Neurobiology·A R Lieberman
Jul 1, 1995·The Journal of Cell Biology·M D EhlersV E Koliatsos
May 1, 1995·Journal of Neuroscience Research·X Lu, P M Richardson
May 1, 1993·Journal of Neurocytology·X Lu, P M Richardson
Aug 1, 1993·Journal of Neuroscience Research·H Z ShengP G Nelson

❮ Previous
Next ❯

Citations

Feb 13, 1999·Progress in Neurobiology·M J Millan
Dec 17, 2008·Neurological Research·Andrew M HartMikael Wiberg
Jan 10, 2009·Brain Research·Michael P JankowskiKathryn M Albers
Mar 16, 2004·The European Journal of Neuroscience·Stefan BloechlingerClifford J Woolf
Jul 6, 2007·The European Journal of Neuroscience·Floor J StamJoost Verhaagen
Oct 15, 2003·Neuron·Lawrence S B Goldstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.