Temporal variability of urinary levels of nonpersistent insecticides in adult men

Journal of Exposure Analysis and Environmental Epidemiology
John D MeekerRuss Hauser

Abstract

Widespread application of contemporary-use insecticides results in low-level exposure for a majority of the population through a variety of pathways. Urinary insecticide biomarkers account for all exposure pathways, but failure to account for temporal within-subject variability of urinary levels can lead to exposure misclassification. To examine temporal variability in urinary markers of contemporary-use insecticides, nine repeated urine samples were collected over 3 months from 10 men participating in an ongoing study of male reproductive health. These 90 samples were analyzed for urinary metabolites of chlorpyrifos (3,5,6-trichloro-2-pyridinol (TCPY)) and carbaryl (1-naphthol (1N)). Volume- based (unadjusted), as well as creatinine (CRE)- and specific gravity (SG)-adjusted concentrations were measured. TCPY had low reliability with an intraclass correlation coefficient between 0.15 and 0.21, while 1N was moderately reliable with an intraclass correlation coefficient between 0.55 and 0.61. When the 10 men were divided into tertiles based on 3-month geometric mean TCPY and 1N levels, a single urine sample performed adequately in classifying a subject into the highest or lowest exposure tertiles. Sensitivity and specificity rang...Continue Reading

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Citations

Mar 28, 2008·Journal of Exposure Science & Environmental Epidemiology·Panos G GeorgopoulosLarry Reiter
Apr 1, 2010·Journal of Exposure Science & Environmental Epidemiology·Anne M RiedererChensheng Lu
May 17, 2012·Journal of Exposure Science & Environmental Epidemiology·Lesa L AylwardSean M Hays
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Nov 15, 2011·BMC Public Health·Karen S GaleaMartie van Tongeren
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Dec 21, 2006·Journal of Occupational Medicine and Toxicology·Sandra YucraGustavo F Gonzales
Sep 30, 2010·Environmental Health Perspectives·John D MeekerRuss Hauser
Feb 22, 2008·Environmental Health Perspectives·Shruthi MahalingaiahRuss Hauser
Mar 13, 2008·Environmental Health Perspectives·Antonia M CalafatLarry L Needham
Jan 21, 2012·Environmental Health Perspectives·Joe M BraunRuss Hauser
Dec 12, 2013·Environmental Health Perspectives·Kathleen R AttfieldChensheng Lu
Dec 8, 2004·Environmental Health Perspectives·John D MeekerRuss Hauser
Nov 17, 2006·Environmental Health Perspectives·Dana B Barr, Jürgen Angerer
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Nov 8, 2014·Journal of Occupational and Environmental Medicine·Michał RadwanWojciech Hanke
Jun 22, 2006·Journal of Exposure Science & Environmental Epidemiology·Deanna P ScherKathy A Brzak

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