PMID: 9423864Jan 10, 1998Paper

Temporal variation of the merozoite surface protein-2 gene of Plasmodium falciparum

Infection and Immunity
Damon P EisenR L Coppel

Abstract

Extensive polymorphism of key parasite antigens is likely to hamper the effectiveness of subunit vaccines against Plasmodium falciparum infection. However, little is known about the extent of the antigenic repertoire of naturally circulating strains in different areas where malaria is endemic. To address this question, we conducted a study in which blood samples were collected from parasitemic individuals living within a small hamlet in Western Irian Jaya and subjected to PCR amplification using primers that would allow amplification of the gene encoding merozoite surface protein-2 (MSP2). We determined the nucleotide sequence of the amplified product and compared the deduced amino acid sequences to sequences obtained from samples collected in the same hamlet 29 months previously. MSP2 genes belonging to both major allelic families were observed at both time points. In the case of the FC27 MSP2 family, we observed that the majority of individuals were infected by parasites expressing the same form of MSP2. Infections with parasites expressing 3D7 MSP2 family alleles were more heterogeneous. No MSP2 alleles observed at the earlier time point were detectable at the later time point, either for the population as a whole or for ind...Continue Reading

References

Sep 1, 1992·The American Journal of Tropical Medicine and Hygiene·R L AnthonyB Subianto
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J A SmytheR F Anders
Mar 1, 1990·Molecular and Biochemical Parasitology·J A SmytheR F Anders
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J A SmytheR F Anders
Jan 1, 1995·The American Journal of Tropical Medicine and Hygiene·F NtoumiO Mercereau-Puijalon
Oct 1, 1993·Molecular and Biochemical Parasitology·Q BickleR L Coppel
Jan 1, 1996·The American Journal of Tropical Medicine and Hygiene·P DaubersiesP Druilhe
Jun 1, 1996·The American Journal of Tropical Medicine and Hygiene·H ContaminO Mercereau-Puijalon
Feb 1, 1996·Annals of Tropical Medicine and Parasitology·M J BangsD B Subianto
Apr 1, 1996·Molecular and Biochemical Parasitology·V M MarshallR L Coppel

❮ Previous
Next ❯

Citations

Mar 25, 2004·Infection and Immunity·J Andrew PearceRobin F Anders
Jul 5, 2008·Malaria Journal·Grace W MwangokaLeonard Eg Mboera
Jan 8, 2004·The Medical Journal of Australia·Jeffrey N HannaBrian L Montgomery

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.