Temporally irregular mnemonic persistent activity in prefrontal neurons of monkeys during a delayed response task

Journal of Neurophysiology
Albert CompteXiao-Jing Wang

Abstract

An important question in neuroscience is whether and how temporal patterns and fluctuations in neuronal spike trains contribute to information processing in the cortex. We have addressed this issue in the memory-related circuits of the prefrontal cortex by analyzing spike trains from a database of 229 neurons recorded in the dorsolateral prefrontal cortex of 4 macaque monkeys during the performance of an oculomotor delayed-response task. For each task epoch, we have estimated their power spectrum together with interspike interval histograms and autocorrelograms. We find that 1). the properties of most (about 60%) neurons approximated the characteristics of a Poisson process. For about 25% of cells, with characteristics typical of interneurons, the power spectrum showed a trough at low frequencies (<20 Hz) and the autocorrelogram a dip near zero time lag. About 15% of neurons had a peak at <20 Hz in the power spectrum, associated with the burstiness of the spike train; 2). a small but significant task dependency of spike-train temporal structure: delay responses to preferred locations were characterized not only by elevated firing, but also by suppressed power at low (<20 Hz) frequencies; and 3). the variability of interspike in...Continue Reading

References

Nov 1, 1992·Journal of Neurophysiology·G M Ghose, R D Freeman
Jun 1, 1992·Journal of Neurophysiology·M P YoungS Yamane
Mar 1, 1990·Trends in Neurosciences·B W Connors, M J Gutnick
Jan 31, 1992·Science·A Baddeley
May 1, 1989·Journal of Neurophysiology·A M AertsenG Palm
Feb 1, 1989·Journal of Neurophysiology·S FunahashiP S Goldman-Rakic
May 1, 1971·Journal of Neurophysiology·K Kubota, H Niki
Aug 13, 1971·Science·J M Fuster, G E Alexander
Jan 1, 1995·Annual Review of Neuroscience·W Singer, C M Gray
Mar 1, 1995·Neuron·P S Goldman-Rakic
Aug 1, 1994·Current Opinion in Neurobiology·M N Shadlen, W T Newsome
Mar 10, 1995·Science·J E Lisman, M A Idiart
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·G McCarthyR G Shulman
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J N Sanes, J P Donoghue
Jun 17, 1993·Nature·J JonidesM A Mintun
Apr 1, 1996·Current Opinion in Neurobiology·A Treisman
May 1, 1996·Journal of Neurophysiology·G R HoltR J Douglas
Jun 1, 1996·Journal of Neurophysiology·M S Livingstone
Feb 1, 1996·Vision Research·D C KiperJ A Movshon
Aug 1, 1996·Journal of Neurophysiology·C Constantinidis, M A Steinmetz
Feb 3, 1998·Proceedings. Biological Sciences·R BaddeleyE T Rolls
Aug 11, 1998·Neural Computation·C van Vreeswijk, H Sompolinsky
Jan 7, 1999·Journal of Computational Neuroscience·M Camperi, X J Wang
Apr 9, 1999·Nature Neuroscience·J E LismanX J Wang
Mar 11, 2000·Journal of Neurophysiology·D DurstewitzT J Sejnowski
May 16, 2000·Journal of Computational Neuroscience·N Brunel
Dec 23, 2000·Science·J B TenenbaumJ C Langford

❮ Previous
Next ❯

Citations

May 16, 2006·Journal of Computational Neuroscience·Sandro RomaniGianluigi Mongillo
May 19, 2009·Journal of Computational Neuroscience·Adrián Ponce-AlvarezAlexa Riehle
Sep 10, 2010·Journal of Computational Neuroscience·Harel Z Shouval, Jeffrey P Gavornik
Sep 3, 2011·Journal of Computational Neuroscience·Sergio Oscar Verduzco-FloresBard Ermentrout
May 16, 2003·Nature·Yousheng ShuDavid A McCormick
Aug 21, 2013·Nature Neuroscience·Sukbin Lim, Mark S Goldman
Oct 27, 2006·Nature Neuroscience·Emilio Salinas
Jul 31, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James David JentschAntonieta Lavin
Apr 7, 2005·Journal of Cognitive Neuroscience·Gustavo Deco, Edmund T Rolls
Dec 1, 2006·Neural Computation·Alfonso RenartNéstor Parga
Dec 19, 2007·Neural Computation·Arunava BanerjeeAlexandre Pouget
May 15, 2013·Neural Computation·Andreas Steimer, Rodney Douglas
Sep 12, 2007·PLoS Computational Biology·Yasser Roudi, Peter E Latham
Jul 14, 2009·PLoS Computational Biology·Shigeru ShinomotoKeisuke Toyama
Jun 10, 2010·PLoS Computational Biology·Mikael LundqvistAnders Lansner
Sep 3, 2010·PLoS Computational Biology·Botond Szatmáry, Eugene M Izhikevich
Mar 8, 2011·PLoS Computational Biology·Martin Boerlin, Sophie Denève
May 10, 2012·PLoS Computational Biology·Kyriaki Sidiropoulou, Panayiota Poirazi
Apr 18, 2013·PLoS Computational Biology·Adam Ponzi, Jeffery R Wickens
Jul 18, 2014·PLoS Computational Biology·Rubén Moreno-Bote
Jan 26, 2013·PloS One·Samuel JohnsonJoaquín J Torres
Jun 28, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marieke R GilmartinKamran Diba
Feb 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Salva ArdidAlbert Compte
Mar 20, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Samuel P BurnsRobert M Shapley
Oct 11, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Annegret L FalknerB Suresh Krishna
Sep 19, 2012·Progress in Biophysics and Molecular Biology·Matej PlankarIgor Jerman
Jan 15, 2011·Behavioural Brain Research·Zafar U Khan, E Chris Muly
Jun 24, 2010·Current Opinion in Neurobiology·Damian J Wallace, Jason Nd Kerr
Feb 24, 2007·Bio Systems·Roman Borisyuk, Tom Cooke
Jun 4, 2005·The European Journal of Neuroscience·M BodnerJ M Fuster
Oct 24, 2007·The European Journal of Neuroscience·Tadashi Yamazaki, Shigeru Tanaka
Dec 21, 2007·The European Journal of Neuroscience·Daniel Durstewitz, Gustavo Deco
Sep 28, 2007·The European Journal of Neuroscience·John M BurkhardtDonald J Woodward
Aug 26, 2006·Alcoholism, Clinical and Experimental Research·Christopher C LapishL Judson Chandler
Jul 8, 2008·Brain Research·Wei Ji Ma, Alexandre Pouget

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.