May 1, 1977

Temporary characteristics of the process of stem cell inactivation by allogenic lymphocytes

V M Man'koT B Rudneva


The time during which transplated lymphocytes block proliferation and differentiation of non-syngeic stem cells has been determined by retrasplantation of immuno-competent cells from one lethally irradiated recipient to another one. It was established that process of inactivation of CFU by allogeneic lymphocytes proceeds itwo stages. At the first stage, the colonization of recipient's tissues takes place. The colonization of tissues and processes of early recognition are completed during the first hours after transplantation of cell mixtures. At the second stage, the processes of redistribution of injected cells occur and a complete inactivation of stem cells take place. These events are completed in bone marrow and spleen 4-5 days after transplantation of cells mixture, possibly with the participation of lymphocytes sensibilized with the target-cells.

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Mentioned in this Paper

Mice, Inbred CBA
Colony-Forming Units, Hematopoietic
Allogeneic lymphocytes
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Bone Marrow
Hybridization, Intraspecies
Cell Differentiation Process
Spleen Tissue

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