Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits

Scientific Reports
Karen KrukowskiSusanna Rosi

Abstract

Microglia are the main immune component in the brain that can regulate neuronal health and synapse function. Exposure to cosmic radiation can cause long-term cognitive impairments in rodent models thereby presenting potential obstacles for astronauts engaged in deep space travel. The mechanism/s for how cosmic radiation induces cognitive deficits are currently unknown. We find that temporary microglia depletion, one week after cosmic radiation, prevents the development of long-term memory deficits. Gene array profiling reveals that acute microglia depletion alters the late neuroinflammatory response to cosmic radiation. The repopulated microglia present a modified functional phenotype with reduced expression of scavenger receptors, lysosome membrane protein and complement receptor, all shown to be involved in microglia-synapses interaction. The lower phagocytic activity observed in the repopulated microglia is paralleled by improved synaptic protein expression. Our data provide mechanistic evidence for the role of microglia in the development of cognitive deficits after cosmic radiation exposure.

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Citations

Apr 16, 2020·Journal of Neurophysiology·Gilles R ClémentWilliam H Paloski
Jan 18, 2020·AJNR. American Journal of Neuroradiology·J J BevelacquaS M J Mortazavi
Nov 30, 2018·International Journal of Molecular Sciences·Karen KrukowskiSusanna Rosi
Jan 18, 2019·International Journal of Molecular Sciences·Carli B JonesCatherine M Davis
Sep 29, 2019·The New Bioethics : a Multidisciplinary Journal of Biotechnology and the Body·Konrad Szocik, Martin Braddock
May 21, 2020·Journal of Neuroinflammation·Barrett D AllenMunjal M Acharya
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Sep 19, 2020·International Journal of Radiation Biology·Eloise ParisetSylvain V Costes
Nov 17, 2020·Frontiers in Behavioral Neuroscience·Vipan K PariharCharles L Limoli
Jan 5, 2021·Radiation and Environmental Biophysics·S S SorokinaV A Pikalov
Mar 7, 2021·Trends in Neurosciences·Erin M Gibson, Michelle Monje
Nov 13, 2020·Neurochemistry International·Kazuya MiyanishiJunya Tanaka
Dec 2, 2020·Neuroscience Letters·Maria Serena PaladiniSusanna Rosi
Apr 28, 2021·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Catherine M DavisDawn E Bowles
May 14, 2021·Frontiers in Psychology·Henderika de Vries, William Khoury-Hanold
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Jul 25, 2021·International Journal of Molecular Sciences·Alyssa TidmoreRichard A Britten
Aug 28, 2021·International Journal of Molecular Sciences·Peter M KleinCharles L Limoli
Oct 17, 2021·Journal of Neuroinflammation·Xi FengSusanna Rosi

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Methods Mentioned

BETA
gene
flow cytometry
X-ray
FACS
PCR
Protein Assay

Software Mentioned

Image
[UNK]
Studio
Prism
Ethovision XT
GERM

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