Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Albert TenesaMalcolm G Dunlop

Abstract

To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival. To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex. None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality. We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.

References

Feb 1, 1996·Journal of Epidemiology and Community Health·M J GartonI T Russell
Apr 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emma DotorAlberto Villanueva
Mar 3, 2007·Cancer Research·Jérôme GalonFranck Pagès
Apr 10, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Evropi TheodoratouHarry Campbell
Oct 9, 2007·The Lancet Oncology·Linda S LindströmKamila Czene
Jan 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jong Gwang KimSoo-Han Jun
Dec 31, 2008·International Journal of Cancer. Journal International Du Cancer·Thibaud KoesslerPaul D P Pharoah
May 13, 2009·Nature Reviews. Genetics·Albert Tenesa, Malcolm G Dunlop
Aug 20, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mine S CicekStephen N Thibodeau

❮ Previous
Next ❯

Citations

May 29, 2013·Carcinogenesis·Anna AbulíUNKNOWN Gastrointestinal Oncology Group of Spanish Gastroenterological Association
Nov 6, 2010·Japanese Journal of Clinical Oncology·Amit Man JoshiYohichi Yasunami
Oct 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anna E CoghillCornelia M Ulrich
Apr 23, 2013·Surgery Today·Satoru YamaguchiHiroyuki Kato
Feb 3, 2012·Breast Cancer Research and Treatment·Astrid A OutPeter Devilee
Apr 28, 2012·Familial Cancer·Bruno BuecherJean-Christophe Saurin
May 17, 2011·Current Colorectal Cancer Reports·Jeffrey K Lee, Andrew T Chan
Jul 22, 2014·Journal of Surgical Oncology·Yuan-Tzu LanShih-Ching Chang
May 28, 2014·Genes, Chromosomes & Cancer·Stefano GerolaMichael Neumaier
Mar 31, 2015·Pharmacogenetics and Genomics·Lieke H van Huis-TanjaHenk-Jan Guchelaar
Jul 5, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michael J ProctorDonald C McMillan
Jun 2, 2017·International Journal of Cancer. Journal International Du Cancer·Nan WangWei Zheng
Oct 24, 2018·Genes, Chromosomes & Cancer·Nan SongJae Hwan Oh
Jul 5, 2019·International Journal of Cancer. Journal International Du Cancer·Yazhou HeMaria Timofeeva
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Yasemin Benderli CihanHasan Mutlu
Dec 5, 2019·Clinical and Translational Gastroenterology·Korbinian WeiglHermann Brenner
Aug 24, 2018·British Journal of Cancer·Evropi TheodoratouMalcolm G Dunlop
Aug 29, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Linda T HirakiAndrew T Chan
Apr 16, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher G SmithJeremy P Cheadle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Mine S CicekStephen N Thibodeau
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Jinliang XingZhinan Chen
© 2021 Meta ULC. All rights reserved