Ten recommendations for supporting open pathogen genomic analysis in public health.

Nature Medicine
Allison BlackTrevor Bedford

Abstract

Increasingly, public-health agencies are using pathogen genomic sequence data to support surveillance and epidemiological investigations. As access to whole-genome sequencing has grown, greater amounts of molecular data have helped improve the ability to detect and track outbreaks of diseases such as COVID-19, investigate transmission chains and explore large-scale population dynamics, such as the spread of antibiotic resistance. However, the wide adoption of whole-genome sequencing also poses new challenges for public-health agencies that must adapt to support a new set of expertise, which means that the capacity to perform genomic data assembly and analysis has not expanded as widely as the adoption of sequencing itself. In this Perspective, we make recommendations for developing an accessible, unified informatic ecosystem to support pathogen genomic analysis in public-health agencies across income settings. We hope that the creation of this ecosystem will allow agencies to effectively and efficiently share data, workflows and analyses and thereby increase the reproducibility, accessibility and auditability of pathogen genomic analysis while also supporting agency autonomy.

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Citations

Aug 22, 2020·PLoS Biology·Chaney C KalinichAnderson F Brito
Aug 2, 2020·Nature Human Behaviour·William Marciel de SouzaNuno Rodrigues Faria
Dec 7, 2020·Briefings in Bioinformatics·Matteo ChiaraGraziano Pesole
Dec 22, 2020·Briefings in Bioinformatics·Anna BernasconiStefano Ceri
Jan 6, 2021·Radiology·Emily B TsaiCarol C Wu
Feb 26, 2021·Journal of Clinical Microbiology·Michael R WeigandM Lucia Tondella
Jul 1, 2021·Journal of Open Source Software·John HuddlestonEmma B Hodcroft
Jun 8, 2021·Bioinformatics·Miguel RoncoroniFrederik Coppens
Jul 10, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James B PettengillRuth Timme

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Software Mentioned

PulseNet
Galaxy
PHA4GE
BaseSpace
BioNumerics

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