PMID: 2501509Jul 1, 1989Paper

TEN versus TPN following major abdominal trauma--reduced septic morbidity

The Journal of Trauma
F A MooreV M Peterson

Abstract

Recent animal models suggest that enteral feeding (TEN) compared to parenteral nutrition (TPN) improves resistance to infection. This prospective clinical trial examined the impact of early TEN vs. TPN in the critically injured. Seventy-five patients with an abdominal trauma index (ATI) greater than 15 and less than 40 were randomized at initial laparotomy to receive either TEN (Vivonex TEN) or TPN (Freamine HBC 6.9% and Trophamine 6%); both regimens contained 2.5% fat, 33% branched chain amino acids, and had a calorie to nitrogen ratio of 150:1. TEN was delivered via a needle catheter jejunostomy. Nutritional support was initiated within 12 hours postoperatively in both groups, and infused at a rate sufficient to render the patients in positive nitrogen balance. The study groups (TEN = 29 vs TPN = 30) were comparable in age, injury severity and initial metabolic stress. Jejunal feeding was tolerated unconditionally in 25 (86%) of the TEN group. Nitrogen balance remained equivalent throughout the study period, at day 5 TEN = -0.3 +/- 1.0 vs. TPN 0.1 +/- 0.8 gm/day. Traditional nutritional protein markers (albumin, transferrin, and retinol binding protein) were restored better in the TEN group. Infections developed in 5 (17%) of...Continue Reading

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Apr 7, 2010·Pierre singer

Citations

Nov 1, 1993·The International Journal of Eating Disorders·P S Mehler, K L Weiner
Jan 1, 1993·Intensive Care Medicine·D K HeylandG H Guyatt
Sep 1, 1994·Journal of Anesthesia·M YasumotoT Morioka
Jul 1, 1995·Irish Journal of Medical Science·F A ChambersD Phelan
Jun 4, 2008·Langenbeck's Archives of Surgery·Joshua L HermsenKenneth A Kudsk
Mar 3, 2012·Langenbeck's Archives of Surgery·Yoshimasa AkashiToshiharu Yamaguchi
May 4, 2011·Current Gastroenterology Reports·Jinesh P MehtaMihir Kishorchandra Patel
Sep 12, 2000·Current Gastroenterology Reports·A Habib, D F Kirby
Mar 17, 2005·Current Treatment Options in Gastroenterology·Souheil G Abou-AssiMitchell L Schubert
Dec 1, 1989·American Journal of Surgery·C P Page
Feb 22, 1992·Lancet·P D Macnaughton, T W Evans
Feb 1, 1994·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Z J Shu, J S Li
May 1, 1995·Burns : Journal of the International Society for Burn Injuries·I AlicanB C Yeğen
Jan 1, 1996·Nutrition·R DennoD W Wilmore
Dec 2, 2004·Critical Care Nursing Clinics of North America·Vicki J FoxMeredith McClung
Aug 7, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lidija KompanJ Pecar
Aug 7, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Huey-Fang ShangSung-Ling Yeh
May 29, 2000·American Journal of Surgery·C T KlodellD A Spain
Jun 1, 1996·American Journal of Surgery·H C SaxD J Hardy
Dec 1, 1995·American Journal of Surgery·J G MyersJ B Aust
Dec 1, 1995·American Journal of Surgery·K A FoxW D Rappaport
Jun 1, 1997·Disease-a-month : DM·B A Mizock, S Troglia
Jun 5, 2003·Journal of Pediatric Surgery·Barbara E WildhaberDaniel H Teitelbaum
Jan 8, 2000·The Surgical Clinics of North America·R Ferrada, D Birolini
Jan 8, 2000·The Surgical Clinics of North America·E A Deitch, E R Goodman
Sep 27, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·D B A Silk
Jul 1, 1997·Critical Care Clinics·G J Schears, C S Deutschman
Jul 3, 1998·Gastroenterology Clinics of North America·R C DeWitt, K A Kudsk
May 26, 1999·Infectious Disease Clinics of North America·R C DeWitt, K A Kudsk
Feb 13, 2001·Nutrition·N P WoodcockJ MacFie
Nov 15, 2002·Nutrition·Curtis J WrayPer-Olof Hasselgren
May 1, 1997·Nutrition·J P VelezJ I Restrepo
Jul 1, 1998·Nutrition·K A Kudsk

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