Ten Weeks of Infection with a Tissue-Invasive Helminth Protects against Local Immune Complex-Mediated Inflammation, but Not Cutaneous Type I Hypersensitivity, in Previously Sensitized Mice

The Journal of Immunology : Official Journal of the American Association of Immunologists
Holly EvansEdward Mitre

Abstract

In this study, we evaluated the effect chronic helminth infection has on allergic disease in mice previously sensitized to OVA. Ten weeks of infection with Litomosoides sigmodontis reduced immunological markers of type I hypersensitivity, including OVA-specific IgE, basophil activation, and mast cell degranulation. Despite these reductions, there was no protection against immediate clinical hypersensitivity following intradermal OVA challenge. However, late-phase ear swelling, due to type III hypersensitivity, was significantly reduced in chronically infected animals. Levels of total IgG2a, OVA-specific IgG2a, and OVA-specific IgG1 were reduced in the setting of infection. These reductions were most likely due to increased Ab catabolism as ELISPOT assays demonstrated that infected animals do not have suppressed Ab production. Ear histology 24 h after challenge showed infected animals have reduced cellular infiltration in the ear, with significant decreases in numbers of neutrophils and macrophages. Consistent with this, infected animals had less neutrophil-specific chemokines CXCL-1 and CXCL-2 in the ear following challenge. Additionally, in vitro stimulation with immune complexes resulted in significantly less CXCL-1 and CXCL-...Continue Reading

References

Jul 1, 1989·Experimental Parasitology·T Alkarmi, K Behbehani
Jan 29, 2002·International Journal for Parasitology·Alexander W PfaffWolfgang H Hoffmann
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed Elfatih H BashirCathryn Nagler-Anderson
Mar 25, 2004·International Immunology·Gisela WohllebenKlaus J Erb
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew D TaylorRick M Maizels
Nov 9, 2005·The Journal of Experimental Medicine·Mark S WilsonRick M Maizels
Sep 4, 2007·The Journal of Allergy and Clinical Immunology·Fred D Finkelman
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna M DittrichEckard Hamelmann
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sang Kyun ParkHak Sun Yu
Oct 6, 2009·The Journal of Allergy and Clinical Immunology·Peter BagerMads Melbye
Dec 25, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J R FearyJ R Britton
Jul 14, 2010·Cellular & Molecular Immunology·C Edward RoseSun-sang J Sung
Sep 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laurence E ChengRichard M Locksley
Nov 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marina N TorreroEdward Mitre
Mar 1, 2012·Current Medicinal Chemistry·B L MakepeaceS Specht
Mar 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·David LarsonEdward Mitre
Aug 14, 2012·Lancet·Jui-Hung Ko, Wen-Hung Chung
Mar 28, 2013·Journal of Leukocyte Biology·Friederike JönssonPierre Bruhns
May 2, 2014·Frontiers in Immunology·Elmar Pieterse, Johan van der Vlag
Oct 29, 2014·Journal of Visualized Experiments : JoVE·Holly EvansEdward Mitre

❮ Previous
Next ❯

Citations

Dec 14, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Laura KroppEdward Mitre
Jun 27, 2020·American Journal of Rhinology & Allergy·Yun-Fang AnPing-Chang Yang
Jun 25, 2021·Seminars in Immunopathology·E Mitre, A D Klion

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.