Ten-year experience of selective omission of the pretransplant crossmatch test in deceased donor kidney transplantation.

Transplantation
Craig J TaylorJ Andrew Bradley

Abstract

A pretransplant lymphocyte crossmatch (XM) test is usually considered mandatory but may delay deceased donor renal transplantation. We report on the safety and clinical efficacy of omitting the XM when it is predicted to be negative based on sensitization history and human leukocyte antigen-specific antibody screening. From 1998 to 2008, 606 deceased donor kidney transplants were performed at our center and the prospective donor-recipient XM omitted in 257 (42%). In all cases, a negative XM was confirmed retrospectively. Four hundred fourteen (68%) kidneys were donated after brain death (DBD) and 192 (32%) after cardiac death (DCD). The effect of this policy on cold ischemia time (CIT), delayed graft function (DGF), and transplant survival was assessed. Mean CIT was 16.7 hr with a prospective XM and 14.3 hr when it was omitted (P<0.001). The beneficial effect of omitting the XM on DGF was only apparent in recipients of DBD kidneys, where the DGF rate was 28% with a prospective XM and 18% without a prospective XM (P=0.03). The corresponding DGF rate in recipients of DCD kidneys was 52% with a prospective XM and 54% without a prospective XM. Logistic regression analysis, after adjustment for variables that influenced DGF, showed ...Continue Reading

References

Sep 19, 1968·The New England Journal of Medicine·G M WilliamsF Milgrom
Apr 3, 1969·The New England Journal of Medicine·R Patel, P I Terasaki
May 15, 1996·Transplantation·R J MahoneyD A Leeber
Sep 1, 1996·Transplant Immunology·A Robson, S Martin
Jan 12, 1999·Transplantation·A J Matas, D E Sutherland
Mar 8, 2000·Transplantation·P A Dyer, C J Taylor
Oct 12, 2000·The New England Journal of Medicine·S K TakemotoJ M Cecka
Jun 24, 2003·Transplantation·François KleinclaussPhilippe Saas
Jan 14, 2004·Kidney International·Abdulla K SalahudeenWarren May
Apr 16, 2004·Transplantation·Ilias I N DoxiadisFrans H J Claas
Feb 24, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Isabel QuirogaChristopher Darby
Aug 31, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R A BrayH M Gebel
Feb 14, 2007·Transplantation·Gerhard Opelz, Bernd Döhler
Apr 13, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J C MageeA B Leichtman
May 15, 2007·Transplantation·Chris RudgeUNKNOWN Kidney and Pancreas Advisory Group, UK Transplant NHS BT
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Annette M Jackson, Andrea A Zachary
Jun 21, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Domingo HernándezArmando Torres

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Citations

Mar 4, 2014·Transplant Immunology·D MiddletonD Lowe
Sep 18, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·UNKNOWN European Renal Best Practice Transplantation Guideline Development Group
Jan 26, 2010·Transplantation·Mary S Leffell
Sep 25, 2014·Transplant Immunology·Sebastiaan HeidtFrans H J Claas
Jul 11, 2013·Current Opinion in Organ Transplantation·Howard M GebelRobert A Bray
Aug 12, 2015·Transplantation·Sussie ShresthaLorna P Marson
Aug 5, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H M Gebel, R A Bray
Jan 11, 2017·Journal of Immunology Research·Edward J Filippone, John L Farber
Jun 24, 2017·Transplantation·Chris J CallaghanChristopher J E Watson
Dec 22, 2017·Transplantation·Robert S Liwski, Howard M Gebel
Mar 26, 2015·Journal of the American Society of Nephrology : JASN·Ana Konvalinka, Kathryn Tinckam
Apr 27, 2019·HLA : Immune Response Genetics·David TurnerAnn-Margaret Little
Sep 14, 2019·HLA : Immune Response Genetics·Anna B MorrisRobert A Bray
Mar 19, 2011·Current Opinion in Organ Transplantation·Sarah A Hosgood, Michael L Nicholson
Nov 26, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C P JohnsonT M Ellis
Oct 20, 2010·European Journal of Clinical Investigation·Sarah A HosgoodMichael L Nicholson
Feb 22, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Patrizia AmicoStefan Schaub
Jun 15, 2011·Current Opinion in Organ Transplantation·J Michael Cecka
Apr 20, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Chris J CallaghanNikolaos Karydis
Jul 9, 2021·Kidney Research and Clinical Practice·Yohan ParkChul Woo Yang
Sep 24, 2021·International Journal of Immunogenetics·S PeacockJ Worthington

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