PMID: 9531359Apr 8, 1998Paper

Ten-year outcomes for pathologic node-positive patients treated in RTOG 75-06

International Journal of Radiation Oncology, Biology, Physics
G E HanksM V Pilepich

Abstract

This study was conducted to see what fraction of prostate cancer patients with biopsy-proven nodes are free of cancer 10 years after radiation treatment. RTOG protocol #75-06 included 90 patients with biopsy-proven pelvic nodal involvement treated with radiation. They have been continuously follow-up since treatment. When feasible, current prostate-specific antigen (PSA) levels have been solicited from patients clinically cancer-free (no evidence of disease, NED) at 10 years, to confirm cure. The 10-year survival was 29%, the 10-year clinical NED survival 7%. PSA levels were obtained in 2 of 5 10-year clinical NED patients, they were both less than 0.8 ng/ml. The 2 proven cures were both clinical stage T-3, Gleason Score 6 and 8, and had 2 and 1 positive nodes, respectively. Multivariate analysis showed Gleason sum was significantly associated with clinical survival without disease. A small fraction of node-positive patients are cured at 10-year follow-up by radiation therapy (2 of 90 with PSA +3 of 90 by clinical endpoints). Innovative treatment programs should be directed at node-positive patients in an effort to improve the fraction cured.

References

Mar 1, 1987·International Journal of Radiation Oncology, Biology, Physics·M V PilepichK L Martz
Jan 1, 1995·International Journal of Radiation Oncology, Biology, Physics·M E SandsG K Zagars
Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G E HanksT E Schultheiss

❮ Previous
Next ❯

Citations

May 15, 2002·Critical Reviews in Oncology/hematology·Ulka Vaishampayan, Maha Hussain
May 10, 2000·Cancer Biotherapy & Radiopharmaceuticals·M K HasemanT J Polascik
May 18, 1999·Current Opinion in Oncology·E J Small
Feb 25, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Anja M WeidnerFrank Lohr
Jun 19, 2012·Cancer Treatment Reviews·Gilles CréhangeMack Roach
Nov 3, 2011·The Urologic Clinics of North America·Thomas J Pugh, Andrew K Lee
Feb 19, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm D MasonPadraig Warde
Dec 1, 2006·Expert Review of Anticancer Therapy·Tanya B DorffJacek Pinski
May 16, 2006·Cancer·Gregory P SwansonJoseph Basler
Feb 19, 2008·Expert Review of Anticancer Therapy·Ulka Vaishampayan, Maha Hussain
Sep 7, 2018·Clinical & Experimental Metastasis·Ramkishen Narayanan, Timothy G Wilson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.