Ten-year results of preoperative radiation followed by sphincter preservation for rectal cancer: increased local failure rate in nonresponders

Clinical Colorectal Cancer
Ramesh RenganBruce D Minsky

Abstract

The primary objective of this study was to determine the long-term outcome of sphincter preservation with preoperative radiation therapy (RT) and surgical resection in the treatment of distal rectal adenocarcinoma. Between April 1988 and December 1996, 36 (cT2, n=9; cT3, n=27) patients with rectal adenocarcinoma were enrolled on a phase I/II trial of preoperative RT followed by surgical resection. All patients had distal tumors that were clinically judged to require an abdominoperineal resection and received preoperative RT (50.4 Gy) followed by surgery. The median follow-up was 94.5 months (range, 4-187 months). Of the 35 patients in this study who underwent resection, 77% were able to undergo sphincter preservation after preoperative RT. The pathologic complete response rate for these patients was 14%. The 10-year rates of overall survival and local failure for patients undergoing sphincter preservation were 54% and 21%, respectively. The 10-year local failure was 26% in patients with cT3 disease who underwent sphincter preservation. All local failures in this study occurred in patients with cT3 disease undergoing sphincter preservation; however, none of the patients with cT3 disease that was downstaged by preoperative RT exp...Continue Reading

References

Sep 1, 1982·World Journal of Surgery·A G Parks
Feb 1, 1995·International Journal of Radiation Oncology, Biology, Physics·B D MinskyP Paty
Apr 16, 1998·International Journal of Radiation Oncology, Biology, Physics·V ValentiniM Cosimelli
Mar 10, 2001·International Journal of Radiation Oncology, Biology, Physics·A GrannB D Minsky
Jun 8, 2001·International Journal of Radiation Oncology, Biology, Physics·G AdellB Nordenskjöld
Mar 2, 2002·International Journal of Radiation Oncology, Biology, Physics·Claus RödelFranz Rödel
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E TepperR J Mayer
Jun 22, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J FeliuM González Barón
Jul 20, 2002·Diseases of the Colon and Rectum·Catherine BonnelEmmanuel Tiret
Aug 6, 2003·Annals of Surgical Oncology·Jose G GuillemW Douglas Wong
Aug 9, 2003·International Journal of Colorectal Disease·R G H Beets-Tan, G L Beets
Aug 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus RödelRolf Sauer
Oct 31, 2003·Seminars in Radiation Oncology·Larissa K F TempleBruce Minsky
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Pierre GerardPatrice Adeleine
Jun 24, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carlos Fernández-MartosDaniel Almenar
Sep 1, 2004·International Journal of Radiation Oncology, Biology, Physics·Maria Antonietta GambacortaNuma Cellini
Oct 16, 2004·Diseases of the Colon and Rectum·Graham BranaganDerek Finnis
Nov 5, 2004·Annals of Surgical Oncology·Harvey G MooreJose G Guillem
Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B Michael GhadimiThomas Ried
Jul 21, 2005·International Journal of Radiation Oncology, Biology, Physics·Matthew S KatzJose G Guillem
Jul 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ramesh RenganBruce D Minsky

❮ Previous
Next ❯

Citations

Aug 23, 2008·World Journal of Gastroenterology : WJG·Ze-Yu WuHua-Huan Lin
Dec 3, 2014·Journal of Visceral Surgery·F DumontD Goéré
Sep 29, 2006·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P Rouanet
Jun 2, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Genevieve B MeltonSusan L Gearhart
Aug 4, 2007·Diseases of the Colon and Rectum·Ron G LandmannMartin R Weiser
Aug 21, 2007·International Journal of Colorectal Disease·Shingo TsujinakaKen Mizokami
Mar 28, 2009·Annals of Surgical Oncology·John C Mansour, Roderich E Schwarz
Sep 15, 2010·Journal of Attention Disorders·Wenche Andersen HellandMikael Heimann
Dec 7, 2007·The Oncologist·Rob Glynne-Jones, Mark Harrison

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.