Ten years after: reclassification of steroid-responsive genes

Molecular Endocrinology
D C Dean, M M Sanders

Abstract

Although several hundred genes are directly or indirectly regulated by steroid hormones, significant gaps exist in our understanding of the relevant mechanisms, particularly for those genes that do not directly bind intracellular receptors or that exhibit delayed changes in transcription rates upon receptor binding. To assist in defining the mechanism of action of steroid hormones, we are proposing that a standard nomenclature be adopted for classifying steroid-responsive genes, based upon whether the receptors directly bind to the target genes and the kinetics of the response. Three categories are proposed: primary response genes, delayed primary response genes, and secondary response genes.

Citations

Feb 28, 2001·The Journal of Steroid Biochemistry and Molecular Biology·F ZhouE B Thompson
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anilkumar Bettegowda, Miles F Wilkinson
Nov 11, 2009·Molecular Endocrinology·Zhiying HuMiles F Wilkinson
Mar 8, 2000·Environmental Health Perspectives·X LongR M Bigsby
Jun 24, 1999·Environmental Health Perspectives·C Massaad, R Barouki
Aug 23, 2012·PloS One·Subbarayalu PanneerdossManjeet K Rao
Jan 20, 2009·World Journal of Gastroenterology : WJG·Laurie Drozdowski, Alan B R Thomson
May 26, 2001·Biochemical and Biophysical Research Communications·S Vernier-MagninA Fraichard
Sep 11, 2001·Biochemical and Biophysical Research Communications·J F MusardP Adami
Feb 26, 2000·European Journal of Biochemistry·L C TsaiT C Chang
Jan 7, 1999·The Journal of Steroid Biochemistry and Molecular Biology·T MoriH Yokota
Feb 28, 2001·The Journal of Steroid Biochemistry and Molecular Biology·T MoriH Yokota
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·R J Denver
Jun 17, 2008·The Journal of Physiology·Véronique DouardRonaldo P Ferraris
Aug 21, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Trond M Kortner, Augustine Arukwe
May 21, 2008·Journal of Neurochemistry·Hirohito SatoMasahiko Mikuni
Oct 6, 2005·Trends in Endocrinology and Metabolism : TEM·Dawne C Dougherty, Michel M Sanders
May 7, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Raj Kumar, E Brad Thompson
Apr 26, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·V RiderN I Abdou
Nov 4, 1998·Frontiers in Neuroendocrinology·G G KuiperJ A Gustafsson

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