Ten years experience with oral immunosuppressive treatment in adult patients with atopic dermatitis in two academic centres

Journal of the European Academy of Dermatology and Venereology : JEADV
F M GarritsenMarjolein S de Bruin-Weller

Abstract

There is a lack of information on the use oral immunosuppressive drugs in atopic dermatitis (AD) daily practice. A 10-years overview of the use of oral immunosuppressive drugs in patients with severe AD. Medical charts of patients with AD, who received oral immunosuppressive drugs at the Academic Medical Center Amsterdam and in the University Medical Center Utrecht between January 2001 and January 2011, were analysed. Particular attention was paid to patient characteristics, prior treatment, prescribed oral immunosuppressive drugs, the order of use, doses and treatment durations and reasons for discontinuation of treatment. Of 334 patients [53% male, mean age at start of an oral immunosuppressive drug 36.9 years (SD 13.6)] with AD received oral immunosuppressive treatment of which 102 (31%) participated in clinical trials. Cyclosporine A (CyA) was given in 80% of the patients, mycophenolate mofetil or enteric-coated mycophenolate (MMF/EC-MPS) in 31%, azathioprine (AZA) in 14%, methotrexate (MTX) in 11%, systemic glucocorticosteroids in 7% and systemic tacrolimus in 5%. In these academic centra, CyA was the first choice oral immunosuppressive in 252 patients. Reasons for discontinuation of oral immunosuppressive drugs were contr...Continue Reading

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Citations

Aug 24, 2016·The Journal of Dermatological Treatment·J L ThijsM S De Bruin-Weller
Oct 18, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Sharon Seth, David A Khan
Apr 14, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·N KitayamaK Kabashima
Feb 15, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·S Law Ping ManC Droitcourt
Feb 28, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·F M GarritsenM S de Bruin-Weller
Oct 31, 2017·Journal of Cutaneous Medicine and Surgery·Charles W LyndeRonald Vender
Dec 24, 2018·Expert Review of Clinical Immunology·Kadra KalamahaJonathan Rodrigues
Feb 16, 2019·Expert Opinion on Biological Therapy·Jorien van der SchaftMarjolein S de Bruin-Weller
Sep 16, 2017·The Journal of Dermatological Treatment·F M GarritsenM S de Bruin-Weller
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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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