Oct 1, 1989

Tenascin, an extracellular matrix protein, exerts immunomodulatory activities

Proceedings of the National Academy of Sciences of the United States of America
C R RüeggS S Alkan

Abstract

Tenascin is a nonubiquitous extracellular matrix protein mainly expressed during morphogenesis in embryonal life. In adults it reappears in malignant tumors and during inflammation and tissue repair. Extracellular matrix proteins can alter cell morphology, adhesion, motility, differentiation, and growth. Since cells of the immune system can express receptors for extracellular matrix, we investigated the effects of tenascin on human monocytes and T and B lymphocytes. Tenascin inhibited monocyte adhesion to fibronectin and enhanced the LFA-1 (lymphocyte function-associated antigen 1)-dependent clustering of Epstein-Barr virus-transformed B cells. The physiological consequences of the effects of tenascin were studied in several T-cell activation models. Tenascin inhibited T-cell activation induced by a soluble antigen (tetanus toxoid), alloantigens, or the mitogen concanavalin A. However, T-cell activation with phytohemagglutinin, crosslinked anti-CD3 antibody, or a mixture of ionomycin and phorbol ester was not inhibited by tenascin. Tenascin did not prevent interleukin 2-dependent T-cell growth or the cytolytic activity of an antigen-specific CD4+ T-cell clone. These results suggest that tenascin alters the adhesion properties o...Continue Reading

  • References34
  • Citations90

References

  • References34
  • Citations90

Citations

Mentioned in this Paper

Soluble antigen
ITGB2 wt Allele
Immune System
T-Lymphocyte
Exertion
Antigen-Presenting Cells
TNC gene
Immunologic Adjuvants
Tetanus Vaccine
Cell Motility

About this Paper

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