Tenascin-C and carcinoma cell invasion in oral and urinary bladder cancer

Cell Adhesion & Migration
Alexander BerndtMarcus Franz

Abstract

Carcinoma invasion is a complex process regulated by genetic and epigenetic factors as well. A relevant supportive condition for cancer cell migration is the reorganization of the extracellular matrix (ECM), which is realized in an orchestrated multicellular manner including carcinoma cells and stromal fibroblasts. An important key player in the process of ECM reorganization is Tenascin-C (Tn-C). The molecule occurs as different isoforms generated by alternative splicing and de novo glycosylation. Large variants of Tn-C are abundantly re-expressed in the invasive front of many carcinoma types. A special role for initiating migration and accompanied epithelial to mesenchymal transition has been suggested. Here, we review the current knowledge concerning the tumor biological importance of Tn-C, the synthesis and alternative splicing during the invasive process in general, and give an overview on the impact of Tn-C in urothelial carcinoma of the urinary bladder (UBC) and oral squamous cell carcinoma (OSCC).

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Citations

Oct 17, 2015·International Journal of Molecular Sciences·Lukas LacinaKarel Smetana
Jan 15, 2016·Advanced Drug Delivery Reviews·Andrew J Sawyer, Themis R Kyriakides
Dec 17, 2015·Nature Reviews. Urology·Massimo AlfanoAndrea Salonia
Apr 1, 2016·Bioscience, Biotechnology, and Biochemistry·Jian-Cang MaJun Zhao
Sep 11, 2016·Journal of the American Society of Nephrology : JASN·Haiyan FuYouhua Liu
Aug 2, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·George TzanakakisDragana Nikitovic
Jul 16, 2020·Investigative and Clinical Urology·Kwang Woo LeeYoung Ho Kim
Nov 22, 2020·International Journal of Molecular Sciences·Young Eun ChoiSeung-Taek Lee

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Methods Mentioned

BETA
glycosylation
biopsies

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