Tenascin-C and integrins in cancer

Cell Adhesion & Migration
Toshimichi YoshidaKyoko Imanaka-Yoshida

Abstract

Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in cancer tissues dominantly contains large splice variants. Deposition of the stroma promotes the epithelial-mesenchymal transition, proliferation, and migration of cancer cells. It also facilitates the formation of cancer stroma including desmoplasia and angiogenesis. Integrin receptors that mediate the signals of TNC have also been discussed.

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Methods Mentioned

BETA
immunoprecipitation

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