PMID: 7528751Dec 1, 1994Paper

Tenascin-C expression by fibroblasts is elevated in stressed collagen gels

The Journal of Cell Biology
R Chiquet-EhrismannM Chiquet

Abstract

Chick embryo fibroblasts cultured on a collagen matrix exert tractional forces leading to the contraction of unrestrained, floating collagen gels and to the development of tension in attached, restrained gels. On a restrained, attached collagen gel the fibroblasts synthesize large quantities of tenascin-C, whereas in a floating, contracting gel tenascin-C synthesis is decreased. This regulation of tenascin-C synthesis can be observed by the secretion of metabolically labeled tenascin-C into the conditioned medium, as well as by the deposition of tenascin-C into the collagen matrix as judged by immunofluorescence. Regulation appears to occur at the transcriptional level, because when cells on attached or floating collagen gels are transfected with promoter constructs of the tenascin-C gene, luciferase expression driven by the tenascin-C promoter parallels the effects measured for endogenous tenascin-C synthesis, whereas luciferase expression under the control of the SV40 promoter does not depend on the state of the collagen gel. The promoter region responsible for tenascin-C induction on attached collagen gels is distinct from the region important for the induction of tenascin-C by serum, and may define a novel kind of response ...Continue Reading

References

Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E BellC Merrill
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F S JonesG M Edelman
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A D YurochkoS Haskill
Dec 1, 1992·The Journal of Cell Biology·I SadlerM C Beckerle
Apr 1, 1992·The Journal of Cell Biology·M S Kolodney, R B Wysolmerski
May 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Ben-Ze'ev
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F S JonesG M Edelman
Jan 1, 1990·Annual Review of Cell Biology·J Massagué
Feb 1, 1990·Experimental Cell Research·D GullbergK Rubin
Jan 1, 1989·Annual Review of Cell Biology·H P Erickson, M A Bourdon
Nov 7, 1982·Journal of Theoretical Biology·M J BissellG Parry
Feb 1, 1993·The Journal of Cell Biology·R L Juliano, S Haskill
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N ResnickM A Gimbrone

❮ Previous
Next ❯

Citations

May 30, 1998·Cell Motility and the Cytoskeleton·M EastwoodR A Brown
Jan 5, 2000·Cell Motility and the Cytoskeleton·V C MuderaR A Brown
May 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M K GordonJ M Fitch
Jun 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·F S Jones, P L Jones
Oct 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R Chiquet-EhrismannS Schenk
Aug 11, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B MikicE B Hunziker
Oct 19, 2010·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Yutaka NakoshiAtsumasa Uchida
Apr 20, 2004·The International Journal of Biochemistry & Cell Biology·Ruth Chiquet-Ehrismann
Jan 20, 2004·Experimental Eye Research·Wei CuiPeter J McDonnell
Sep 14, 1999·Journal of the American College of Cardiology·K WallnerB G Sharifi
Aug 30, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·B EckesT Krieg
Dec 5, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·P L Jones, F S Jones
Apr 26, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Matthias ChiquetMartin Flück
Dec 22, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·M Chiquet
Apr 1, 1997·Critical Reviews in Oncology/hematology·G Vollmer
Apr 5, 2000·Progress in Retinal and Eye Research·M R Hernandez
Aug 11, 2011·Nature Reviews. Molecular Cell Biology·Nikolce Gjorevski, Celeste M Nelson
Sep 11, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Wesley R LegantViola Vogel
Jul 8, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·R T PrajapatiR A Brown
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Wesley R LegantChristopher S Chen
May 14, 2003·The Journal of Cell Biology·David M McKeanPeter Lloyd Jones
Nov 11, 2008·Tissue Engineering. Part a·Rita I AbousleimanVassilios Sikavitsas
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C HagiosM J Bissell
Sep 29, 2011·Pathology International·Taizo KimuraMasunori Matsuzaki
Feb 25, 2003·Journal of Biomechanical Engineering·Gregory H AltmanGordana Vunjak-Novakovic
Mar 31, 2005·Journal of Biomechanical Engineering·Blayne A RoederSherry L Voytik-Harbin
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Matthias ChiquetAna Sarasa-Renedo
Mar 13, 2010·Fibrogenesis & Tissue Repair·Beate EckesThomas Krieg
Aug 24, 2010·Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology : SMARTT·Catherine K KuoRocky S Tuan
Mar 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshitaka IsoTakashi Katagiri
Jan 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C M WebbE J Mackie
Mar 12, 2011·Annual Review of Biophysics·G V Shivashankar
Oct 31, 2014·Nature Reviews. Molecular Cell Biology·Jay D HumphreyMartin A Schwartz
Oct 20, 2009·Journal of Cell Communication and Signaling·Kim S Midwood, Gertraud Orend
Aug 2, 2011·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Veronika PivodovaJitka Ulrichova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.