PMID: 7539482Jan 1, 1995Paper

Tenascin-C expression during wallerian degeneration in C57BL/Wlds mice: possible implications for axonal regeneration

Journal of Neurocytology
M FruttigerR Martini

Abstract

Schwann cells in the distal stumps of lesioned peripheral nerves strongly express the extracellular matrix glycoprotein tenascin-C. To gain insights into the relationship between Wallerian degeneration, lesion induced tenascin-C upregulation and regrowth of axons we have investigated C57BL/Wlds (C57BL/Ola) mice, a mutant in which Wallerian degeneration is considerably delayed. Since we found a distinct difference in the speed of Wallerian degeneration between muscle nerves and cutaneous nerves in 16-week-old C57BL/Wlds mice, as opposed to 6-week-old animals in which Wallerian degeneration is delayed in both, we chose the older animals for closer investigation. Five days post lesion tenascin-C was upregulated in the muscle branch (quadriceps) but not in the cutaneous branch (saphenous) of the femoral nerve in 16-week-old animals. In addition myelomonocytic cells displaying endogenous peroxidase activity invaded the muscle branch readily whereas they were absent from the cutaneous branch at this time. We could further show that it is only a subpopulation of axon-Schwann cell units (mainly muscle efferents) in the muscle branch which undergo Wallerian degeneration and upregulate tenascin-C at normal speed and that the remaining ax...Continue Reading

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Citations

Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
Dec 28, 2012·Amino Acids·Igor JakovcevskiPavle R Andjus
May 25, 1999·Progress in Neurobiology·R Probstmeier, P Pesheva
Mar 1, 1995·The European Journal of Neuroscience·M FruttigerR Martini
Jan 4, 2013·Journal of Neuroinflammation·Naoki KatoMasato Ogata
Aug 3, 2001·The Journal of Physiology·T H Gillingwater, R R Ribchester
Sep 23, 2014·Neuroscience·A DeFrancesco-LisowitzR E Zigmond
May 30, 1998·Experimental Neurology·K Torigoe, G Lundborg
Sep 2, 2009·Journal of Intellectual Disability Research : JIDR·P Embregts, M van Nieuwenhuijzen
Jul 5, 2005·Clinical Orthopaedics and Related Research·Ranjan GuptaOswald Steward
May 15, 1996·Journal of Neuroscience Research·M NakicM Schachner

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