Tenascin C in metastasis: A view from the invasive front

Cell Adhesion & Migration
Camille M Lowy, Thordur Oskarsson

Abstract

The extracellular matrix protein tenascin C (TNC) is a large glycoprotein expressed in connective tissues and stem cell niches. TNC over-expression is repeatedly observed in cancer, often at the invasive tumor front, and is associated with poor clinical outcome in several malignancies. The link between TNC expression and poor survival in cancer patients suggests a role for TNC in metastatic progression, which is responsible for the majority of cancer related deaths. Indeed, functional studies using mouse models are revealing new roles of TNC in cancer progression and underscore its important contribution to the development of metastasis. TNC has a pleiotropic role in advancing metastasis by promoting migratory and invasive cell behavior, angiogenesis and cancer cell viability under stress. TNC is an essential component of the metastatic niche and modulates stem cell signaling within the niche. This may be crucial for the fitness of disseminated cancer cells confronted with a foreign environment in secondary organs, that can exert a strong selective pressure on invading cells. TNC is a compelling example of how an extracellular matrix protein can provide a molecular context that is imperative to cancer cell fitness in metastasis.

References

Oct 1, 1992·Japanese Journal of Cancer Research : Gann·H KawakatsuT Sakakura
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·T ShojiS Morii
Feb 1, 1990·Differentiation; Research in Biological Diversity·J E FergusonM W Ferguson
Oct 15, 1990·International Journal of Cancer. Journal International Du Cancer·P G NataliL Zardi
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E J MackieT Sakakura
May 6, 1988·Cell·R Chiquet-EhrismannM Chiquet
Jan 1, 1994·Cell Adhesion and Communication·L BorsiL Zardi
Oct 1, 1994·Journal of Cutaneous Pathology·H Tuominen, M Kallioinen
Dec 31, 1997·Molecular Biology of the Cell·D FischerJ C Adams
Aug 1, 1997·The British Journal of Ophthalmology·H MaserukaA B Tullo
Feb 12, 1998·British Journal of Cancer·H KusagawaT Sakakura
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·B T Mossman, A Churg
May 29, 1998·Nature·A F OberhauserJ M Fernandez
Jun 17, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·M SeiffertG Klein
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T JahkolaI Virtanen
Feb 11, 1999·The New England Journal of Medicine·T W JacobsS J Schnitt
Dec 14, 1999·Molecular Human Reproduction·S C BellT M Malak
Dec 11, 1999·Virchows Archiv : an International Journal of Pathology·T YoshidaT Sakakura
Aug 23, 2000·The Journal of Cell Biology·M B WenkJ E Schwarzbauer
Sep 23, 2000·Archives of Dermatological Research·M A LatijnhouwersJ Schalkwijk
Dec 6, 2000·Gynecologic Oncology·C GoepelH Koelbl
Jul 17, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·K Imanaka-YoshidaT Yoshida
Jul 27, 2001·The Journal of Cell Biology·C S SwindleA Wells
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M D Puente NavazoC Rüegg
Dec 4, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E IoachimN Pavlidis
Feb 28, 2003·Histopathology·R Kaarteenaho-WiikV L Kinnula
Apr 16, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·R RaitzV C Araújo
May 21, 2003·Genes & Development·Gabriela DontuMax S Wicha
May 22, 2003·The American Journal of Pathology·Takatsugu TsunodaToshimichi Yoshida
Oct 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shin-Ichi AishimaMasazumi Tsuneyoshi
Nov 18, 2003·International Journal of Cancer. Journal International Du Cancer·Keiichiro TanakaMoriaki Kusakabe
Apr 3, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Olivier De WeverMarc Mareel
Apr 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Supaporn SuwiwatDavid J Horsfall

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Citations

Jan 26, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Timothy N Trotter, Yang Yang
Nov 1, 2015·Advanced Drug Delivery Reviews·Hinke A B MulthauptJohn R Couchman
Feb 1, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Anna M Marzeda, Kim S Midwood
Dec 6, 2017·BMC Complementary and Alternative Medicine·Marianne SchmidtUlrike Holzgrabe
Jul 11, 2018·The British Journal of Radiology·Jiacheng SongHaibin Shi
Oct 26, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hiroyuki KatoAna J Coito
Aug 26, 2017·Neurosurgical Review·Moncef BerhoumaFrançois Cotton
Feb 9, 2019·International Journal of Cancer. Journal International Du Cancer·Martin NurmikElisabeth Letellier
Jun 4, 2019·Journal of Alzheimer's Disease : JAD·Karolina MintaUlf Andreasson
Jul 10, 2019·The Journal of Clinical Investigation·Irina PrimacAgnès Noel
Jan 23, 2020·Cells·Marco Montagner, Sirio Dupont
Apr 9, 2020·Cell Communication and Signaling : CCS·Roghayyeh BaghbanPeyman Zare
Mar 13, 2020·Seminars in Liver Disease·Luca FabrisGregory J Gores
Jun 28, 2017·Proceedings of the National Academy of Sciences of the United States of America·Vasilena GochevaTyler Jacks
Feb 26, 2019·Technology in Cancer Research & Treatment·Xinliang MingJiancheng Tu
Mar 9, 2019·Clinical & Experimental Metastasis·Mei Qi KwaCord Brakebusch
Aug 23, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Victor G MartinezSophie E Acton
Jan 1, 2020·Scientific Reports·Jian-Fei ZhangXin-Dong Wang
Nov 23, 2016·Journal of Cell Science·Kim S MidwoodGertraud Orend
Oct 14, 2017·Arkhiv patologii·O P PopovaA A Ivanov
Feb 12, 2020·JCI Insight·Heather M BrechbuhlPeter Kabos
Sep 29, 2017·Cellular and Molecular Life Sciences : CMLS·Justyna Mikuła-PietrasikKrzysztof Książek
Jun 28, 2017·ELife·Christian TiedeDarren Charles Tomlinson
Aug 24, 2019·Reproduction in Domestic Animals = Zuchthygiene·Min Hee ParkSeung Tae Lee
Jul 28, 2019·Journal of Clinical Medicine·Tatiana S GerashchenkoVladimir M Perelmuter
Jul 25, 2019·Cancers·Giulia M StellaChandra Bortolotto
Oct 21, 2020·Oncogene·Inbar AngelDinorah Friedmann-Morvinski
Jan 14, 2018·Cancer Research·Sana SarviValerie G Brunton

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Methods Mentioned

BETA
xenograft
GTPases
GTPase
transgenic

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