Tenascin-C is induced with progressive pulmonary vascular disease in rats and is functionally related to increased smooth muscle cell proliferation

Circulation Research
P L Jones, Marlene Rabinovitch

Abstract

Tenascin-C, an extracellular matrix glycoprotein prominent during tissue remodeling, has been linked to cell migration, proliferation, and apoptosis. To determine its potential role in the pathobiology of pulmonary hypertension, we compared tenascin expression in adult and infant rat pulmonary arteries (PAs) after injection of the toxin monocrotaline. Immunohistochemistry, in situ hybridization, and Northern blot analysis demonstrated induction of tenascin in adult rat central and peripheral PA. Tenascin was not, however, detected in infant vessels, which show spontaneous regression of vascular lesions. To determine a function for tenascin, we correlated its expression with evidence of apoptosis and cell proliferation using the TdT-mediated dUTP-biotin nick end labeling (TUNEL) assay and 5-bromo-2'-deoxyuridine labeling, respectively. Apoptosis was observed only in the adult rat PA endothelial cell layer, preceding the induction of tenascin, which colocalized both temporally and spatially with proliferating smooth muscle cells (SMCs). A cause-and-effect relationship was documented in cultured rat PA SMCs, where tenascin promoted growth in response to basic fibroblast growth factor and was a prerequisite for epidermal growth fac...Continue Reading

References

Nov 1, 1992·European Journal of Biochemistry·P EndM Chiquet
Nov 11, 1992·International Journal of Cancer. Journal International Du Cancer·L BorsiL Zardi
Jan 1, 1991·The British Journal of Dermatology·J SchalkwijkE J Mackie
Nov 1, 1991·The Journal of Cell Biology·J E Murphy-UllrichM Höök
Jan 1, 1991·The Journal of Investigative Dermatology·V A LightnerR P Hall
Jan 1, 1990·Annals of the New York Academy of Sciences·E B Clark, N Hu
May 1, 1986·The Journal of Cell Biology·K L CrossinG M Edelman
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E J MackieT Sakakura
Dec 1, 1988·The Journal of Cell Biology·E J MackieD Liverani
Nov 1, 1989·The Journal of Pathology·G W Stamp
Sep 1, 1987·The Journal of Cell Biology·H P Erickson, H C Taylor
Sep 1, 1972·The Journal of Cell Biology·T Elsdale, J Bard
Jan 1, 1974·British Journal of Diseases of the Chest·B MeyrickL Reid
Dec 1, 1993·Developmental Biology·S MeinersH M Geller
Feb 1, 1994·Developmental Biology·S L YoungH P Erickson
Dec 1, 1994·The Journal of Cell Biology·R Chiquet-EhrismannM Chiquet
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·C D RoskelleyM J Bissell
May 1, 1995·Journal of Vascular Research·A W HahnT J Resink
Apr 1, 1995·The Journal of Pathology·W A WallaceD M Salter
Jan 1, 1993·Journal of Cardiovascular Pharmacology·B L Langille
Dec 1, 1994·American Journal of Respiratory Cell and Molecular Biology·N F VoelkelW P Arend
Feb 1, 1993·The Journal of Cell Biology·R L Juliano, S Haskill
Feb 1, 1996·The Journal of Surgical Research·C ChenA B Lumsden
Feb 1, 1996·American Journal of Respiratory Cell and Molecular Biology·D A QuinnC A Hales

❮ Previous
Next ❯

Citations

Aug 6, 2011·Cellular and Molecular Life Sciences : CMLS·Kim S MidwoodGertraud Orend
Jun 1, 2011·Intensive Care Medicine·M RevermannR P Brandes
Dec 6, 2006·Archives of Dermatological Research·Miyoko KuboTakahiko Moriguchi
Mar 12, 2011·Clinical Reviews in Allergy & Immunology·Nada KherbeckLuc Mouthon
Nov 5, 2003·Trends in Cardiovascular Medicine·Peter Lloyd Jones
Mar 8, 2002·Atherosclerosis·Kurt WallnerBehrooz G Sharifi
Apr 24, 2001·Pharmacology & Therapeutics·B WeinbergerJ D Laskin
Dec 26, 2001·Pharmacology & Therapeutics·T K Jeffery, J C Wanstall
Aug 21, 2003·Toxicology Letters·Po C ChanAbraham Nyska
Jan 5, 2002·Journal of the American College of Cardiology·Jari SattaYlermi Soini
Sep 14, 1999·Journal of the American College of Cardiology·K WallnerB G Sharifi
Dec 5, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·P L Jones, F S Jones
Dec 22, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M Rabinovitch
Dec 2, 2010·Nature Reviews. Drug Discovery·Friedrich GrimmingerHossein A Ghofrani
Oct 20, 1998·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·A E Schultze, R A Roth
Dec 10, 2002·Antioxidants & Redox Signaling·Rubin M Tuder, Norbert F Voelkel
Jun 30, 2011·Cardiovascular Research·Jonathan GolledgeSimon Koblar
May 8, 2009·Human Molecular Genetics·Zheng HuangJames F Martin
Nov 28, 2007·Annual Review of Pathology·Marlene Rabinovitch
Aug 15, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Ahmet CelikRamazan Topsakal
Dec 20, 2012·Circulation Research·Zhou YuGarret A FitzGerald
Feb 2, 2011·Circulation·Miao WangGarret A Fitzgerald
Jul 18, 2002·American Journal of Respiratory and Critical Care Medicine·Robert P JankovA Keith Tanswell
Oct 27, 2004·American Journal of Respiratory and Critical Care Medicine·Trang T-B NguyenStuart J Hirst
Oct 13, 2007·American Journal of Respiratory and Critical Care Medicine·Barbara O MeyrickJames E Loyd
Jul 3, 1998·American Journal of Respiratory Cell and Molecular Biology·H C ThomasH J Segall
Dec 30, 1999·American Journal of Respiratory Cell and Molecular Biology·B H Strauss, M Rabinovitch
Dec 17, 2009·American Journal of Respiratory Cell and Molecular Biology·Seiichiro SakaoNorbert F Voelkel
Jun 19, 2010·American Journal of Respiratory Cell and Molecular Biology·Yinglin LiuBarry L Fanburg
Aug 20, 2009·The Journal of Clinical Investigation·Ethan David CohenEdward E Morrisey
Feb 26, 2011·Journal of Atherosclerosis and Thrombosis·Ahmet CelikIbrahim Ozdogru
Jun 19, 2014·Translational Stroke Research·Kazuhide HamadaHidenori Suzuki
Jan 9, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ugur OrakEkrem Sapmaz
Feb 10, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yoichi MiuraHidenori Suzuki
Sep 27, 2012·Progress in Cardiovascular Diseases·Hala El Chami, Paul M Hassoun
Oct 30, 2012·Revue des maladies respiratoires·S Duong-QuyA T Dinh-Xuan
Jul 10, 2014·Pulmonary Circulation·Vanesa A KaramanianPeter L Jones

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