PMID: 7518292Jan 1, 1994Paper

Tenascin expression in normal human adult skin and skin appendage tumours

Virchows Archiv : an International Journal of Pathology
N ShikataA Tsubura

Abstract

The expression and distribution of tenascin, an extracellular matrix glycoprotein, was investigated immunohistochemically using an anti-human tenascin monoclonal antibody (RCB 1) in formalin-fixed paraffin-embedded tissues obtained from 79 patients with skin appendage tumours, and compared with adjacent normal skin. Tissue specimens were pretreated with actinase and processed by the labelled streptavidin-biotin method. In normal skin, tenascin immunoreactivity was consistently found around the ductal portion of the sweat glands, around the lower part of the hair follicle and hair bulbs, and around or within blood vessels. Immunoreactivity was also observed variably around secretory coils of the sweat glands, and below the epidermis. No immunoreactivity was seen around the sebaceous glands. Tumours originating from sweat glands and hair follicles expressed tenascin around the tumour cells nests, while sebaceous gland tumours were immunonegative. Thus, tenascin expression in skin appendage tumours generally resembled that in corresponding normal tissue.

Citations

Sep 28, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·M A LatijnhouwersJ Schalkwijk
Apr 1, 1995·Journal of Cutaneous Pathology·N ShikataA Tsubura
Nov 7, 2006·Journal of Cutaneous Pathology·Maria LentiniDario Batolo
Jan 30, 2002·Journal of Comparative Pathology·A M R FaustinoH Nederbragt
Jan 1, 1996·The Journal of Pathology·M A LatijnhouwersJ Schalkwijk
Nov 14, 1997·Ultrastructural Pathology·M KostianovskyD Zagzag
May 31, 2003·The American Journal of Dermatopathology·Roy KingPaul B Googe

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