PMID: 11917226Mar 28, 2002Paper

Tenascin expression in normal, hyperplastic, and neoplastic endometrium

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Murat SedeleCanan Figen Sargin

Abstract

Tenascin (TN) is an extracellular matrix glycoprotein (ECM) that participates in embryogenesis and carcinogenesis. The aim of this study was to investigate immunohistochemically the expression of TN in the normal, hyperplastic, and neoplastic endometrium (endometrial adenocarcinoma). In the adenocarcinomas, the results were correlated with patient age, menopausal status, stage, grade, myometrial invasion, and vascular invasion. TN expression was studied in the following cases: proliferative endometrium (10 cases), early secretory endometrium (10), secretory endometrium (10), simple hyperplasia (15), complex hyperplasia (15), atypical hyperplasia (15), and endometrial adenocarcinomas (25). Staining of basal membranes and the cytoplasm of the stromal and epithelial cells was evaluated semiquantitatively. Positive staining was observed in the vascular and glandular basal membranes, stromal cells, and epithelial cells of proliferative, hyperplastic, and neoplastic endometrium. The difference in percentage of stained stromal cells between the neoplastic and the nonneoplastic (proliferative and hyperplastic) endometrium was significant (p<0.005). However, the percentage of stained epithelial cell area in hyperplasia was significantly...Continue Reading

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Citations

Jun 6, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Kimberly H AllisonRochelle L Garica
Aug 9, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Elisabeth J M RobbeJohanna M A Pijnenborg
Apr 28, 2009·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Attila JuhászMargit Balázs
Sep 15, 2005·Endocrine Reviews·Henry N JabbourHilary O D Critchley

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