PMID: 7523604Oct 1, 1994Paper

Tenascin in cerebrospinal fluid is a useful biomarker for the diagnosis of brain tumour

Journal of Neurology, Neurosurgery, and Psychiatry
J YoshidaK Mokuno

Abstract

Tenascin, an extracellular matrix glycoprotein, has been reported to be expressed predominantly on glioma tissue in the CNS, both in a cell associated and an excreted form. Recently, a highly sensitive sandwich type enzyme immunoassay for quantitative determination of tenascin was developed. In the present study, the amount of tenascin in CSF was measured. An increase of tenascin in CSF (> 100 ng/ml) was found in patients with an astrocytic tumour. The concentration was significantly higher (> 300 ng/ml) in high grade astrocytoma (anaplastic astrocytoma and glioblastoma) and a further increase (> 1000 ng/ml) was found in cases of CSF dissemination of high grade astrocytoma. On the other hand, tenascin concentrations were less than 100 ng/ml in non-astrocytic tumours and non-neoplastic neurological diseases, except meningeal dissemination of tumour cells, meningeal stimulation by infection, and subarachnoid haemorrhage. In cases of treated astrocytomas in remission, tenascin was negligible (< 100 ng/ml) in the CSF. The measurement of tenascin in CSF is useful for differential diagnosis of brain tumours and monitoring of astrocytic tumours.

References

Jan 1, 1992·Journal of Neuroimmunology·J B VentimigliaD D Bigner
Oct 21, 1991·International Journal of Cancer. Journal International Du Cancer·D SoulieresG Pelletier
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M GrumetG M Edelman
Sep 1, 1987·The Journal of Cell Biology·H P Erickson, H C Taylor
Aug 1, 1983·Journal of Neuroimmunology·F S WalshS E Moore
Oct 15, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·K WashizuK Takeuchi

❮ Previous
Next ❯

Citations

Apr 1, 1997·Critical Reviews in Oncology/hematology·G Vollmer
Jun 10, 2004·The Journal of Trauma·Heikki T WiikKari A Haukipuro
Aug 25, 2011·Journal of Neurosurgical Anesthesiology·Hidenori SuzukiWaro Taki
Feb 13, 2013·Journal of Nucleic Acids·Yun Min ChangWeihong Tan
Sep 26, 2014·Neuro-oncology·Johan M KrosPing-Pin Zheng
Feb 28, 2015·Acta Neuropathologica·Myron G BestThomas Wurdinger
Nov 24, 2016·Neurochemical Research·A R JayakumarM D Norenberg
Sep 23, 2018·Journal of Neuroscience Research·Hidenori SuzukiMasato Shiba
Feb 27, 2019·Biomarkers in Medicine·Hannah K LooKevin Camphausen
Jul 10, 2019·Cancers·Ander Saenz-AntoñanzasAnder Matheu
Dec 8, 2020·Frontiers in Immunology·Deepak UpretiSheila K Singh
Feb 9, 2021·Frontiers in Immunology·Takeshi Okada, Hidenori Suzuki
Mar 12, 2021·Frontiers in Immunology·Ismaïl HendaouiRuth Chiquet-Ehrismann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.