Tenascins in fibrotic disorders-from bench to bedside

Cell Adhesion & Migration
M KasprzyckaG Haraldsen

Abstract

Although fibrosis is becoming increasingly recognized as a major cause of morbidity and mortality in chronic inflammatory diseases, available treatment strategies are limited. Tenascins constitute a family of matricellular proteins, primarily modulating interactions of cells with other matrix components and growth factors. Data obtained from tenascin C deficient mice show important roles of this molecule in several models of fibrosis. Moreover there is growing evidence that tenascin C has a strong impact on chronic inflammation, myofibroblast differentiation and recruitment. Tenascin C as well as tenascin X has furthermore been shown to affect TGF-β activation and signaling. Taken together these data suggest that these proteins might be important factors in fibrosis development and make them attractive both as biological markers and as targets for therapeutical intervention. So far most clinical research in fibrosis has been focused on tenascin C. This review aims at summarizing our up-to-date knowledge on the involvement of tenascin C in the pathogenesis of fibrotic disorders.

References

Dec 1, 1988·The Journal of Cell Biology·E J MackieD Liverani
Apr 1, 1995·The Journal of Pathology·W A WallaceD M Salter
Jul 1, 1995·European Journal of Biochemistry·C GeffrotinM Vaiman
Jan 1, 1993·International Journal of Legal Medicine·P BetzW Eisenmenger
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·R Kaarteenaho-WiikP Pääkkö
May 5, 1997·The Journal of Cell Biology·R A ClarkT A Springer
Sep 1, 1997·Nature Genetics·G H BurchJ Bristow
Aug 1, 1997·The British Journal of Ophthalmology·H MaserukaA B Tullo
Sep 15, 1998·Biochemical and Biophysical Research Communications·S HibinoK Okumura
Oct 23, 1998·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·H B RichterR Dargel
Dec 18, 1998·The Journal of Investigative Dermatology·Y KoyamaM Kusakabe
Jul 27, 1999·The British Journal of Dermatology·A DalkowskiC C Zouboulis
Sep 14, 1999·Journal of the American College of Cardiology·K WallnerB G Sharifi
Aug 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R Kaarteenaho-WiikP Pääkkö
Jun 16, 2001·Virchows Archiv : an International Journal of Pathology·S MüllerT Aigner
Jul 5, 2001·The American Journal of Pathology·B JianR J Levy
Jul 17, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·K Imanaka-YoshidaT Yoshida
Oct 27, 2001·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·I Sato, K Shimada
May 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jan Henrik HörstrupKai-Uwe Eckardt
Jul 8, 2003·The Journal of Pathology·Ruth Chiquet-Ehrismann, Matthias Chiquet
Mar 3, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Kajiwara KenjiKohno Nobuoki
Jan 25, 2005·Experimental & Molecular Medicine·David C PaikM David Tilson
Jun 24, 2005·The American Journal of Pathology·Masashi TamaokiToshimichi Yoshida
May 31, 2006·World Journal of Gastroenterology : WJG·Dariusz-Marek LebensztejnDetlef Schuppan
Jun 20, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kaori Ihida-StansburyPeter Lloyd Jones
Nov 3, 2006·FEBS Letters·Claire LethiasJean-Yves Exposito
Nov 24, 2006·The Journal of Pathology·A El-KarefK Imanaka-Yoshida
Nov 28, 2006·European Journal of Immunology·Hiroki NakaharaOsamu Taguchi
Jul 20, 2007·Biochemical Society Transactions·A TrebaulK S Midwood
Sep 25, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter BoorJürgen Floege
Dec 29, 2007·The Journal of Pathology·T A Wynn
Apr 22, 2008·Alcoholism, Clinical and Experimental Research·Charles S LieberUNKNOWN Veterans Affairs Cooperative Study 391 Group
Feb 5, 2009·Ultrastructural Pathology·Riitta Kaarteenaho-WiikRaija Sormunen
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masashi KanayamaToshimitsu Uede
Jun 30, 2009·European Heart Journal·Katja Schenke-LaylandWilliam R MacLellan
Sep 2, 2009·Internal Medicine·Keiko HisatomiShigeru Kohno
Oct 6, 2009·Journal of Biomechanics·Boris Hinz
Dec 8, 2009·Science·Richard O Hynes
Jan 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Tomohiro NishiokaKyoko Imanaka-Yoshida
Jan 22, 2010·Biophysical Chemistry·Yoran MargaronClaire Lethias
Jan 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fui G GohKim S Midwood
Aug 28, 2010·Matrix Biology : Journal of the International Society for Matrix Biology·Ekaterina VorotnikovaSusan J Braunhut
Sep 14, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·William A CareyJames D Bristow

❮ Previous
Next ❯

Citations

Jan 15, 2016·Advanced Drug Delivery Reviews·Andrew J Sawyer, Themis R Kyriakides
Apr 1, 2016·Bioscience, Biotechnology, and Biochemistry·Jian-Cang MaJun Zhao
Dec 8, 2015·Mediators of Inflammation·Christophe DesterkeMarie-Caroline Le Bousse-Kerdilès
Sep 1, 2015·PloS One·Gloria Sanchez-AntolínJesus F Bermejo-Martin
Jun 4, 2016·Nature Communications·Swati BhattacharyyaJohn Varga
May 18, 2018·Journal of Atherosclerosis and Thrombosis·Wen GaoKun Xie
Dec 21, 2018·Expert Opinion on Therapeutic Targets·Lingman MaKejiang Lin
Nov 2, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Rivka C StoneMarjana Tomic-Canic
Sep 3, 2020·Vascular Medicine·Jiri Kanta, Anna Zavadakova
Feb 13, 2020·Scientific Reports·Jessica E C JonesStephen R Farmer
Jul 22, 2017·Molecular Medicine Reports·Shinsaku YamaguchiKen-Ichi Matsumoto
Aug 23, 2019·Journal of Cardiovascular Development and Disease·Luis HortellsKatherine E Yutzey
Oct 22, 2020·Clinical Science·Kaj E C BloklandJanette K Burgess
Dec 20, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Beatriz Carmona-HidalgoEduardo Muñoz
Oct 18, 2019·Survey of Ophthalmology·Ciro CostagliolaLeonardo Mastropasqua
Jan 30, 2021·Frontiers in Cell and Developmental Biology·Ana Catarina SilvaDiana S Nascimento
Dec 19, 2020·Frontiers in Immunology·Ken-Ichi Matsumoto, Hiroki Aoki
Nov 22, 2020·International Journal of Molecular Sciences·Young Eun ChoiSeung-Taek Lee
May 14, 2021·Frontiers in Immunology·Lucas Albacete-AlbaceteMiguel Angel Del Pozo

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation
biopsies
biopsy
bronchoalveolar
lavage

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.