Tendon healing affects the multiscale mechanical, structural and compositional response of tendon to quasi-static tensile loading

Journal of the Royal Society, Interface
Benjamin R FreedmanLouis J Soslowsky

Abstract

Tendon experiences a variety of multiscale changes to its extracellular matrix during mechanical loading at the fascicle, fibre and fibril levels. For example, tensile loading of tendon increases its stiffness, with organization of collagen fibres, and increases cell strain in the direction of loading. Although applied macroscale strains correlate to cell and nuclear strains in uninjured tendon, the multiscale response during tendon healing remains unknown and may affect cell mechanosensing and response. Therefore, this study evaluated multiscale structure-function mechanisms in response to quasi-static tensile loading in uninjured and healing tendons. We found that tendon healing affected the macroscale mechanical and structural response to mechanical loading, evidenced by decreases in strain stiffening and collagen fibre realignment. At the micro- and nanoscales, healing resulted in increased collagen fibre disorganization, nuclear disorganization, decreased change in nuclear aspect ratio with loading, and decreased indentation modulus compared to uninjured tendons. Taken together, this work supports a new concept of nuclear strain transfer attenuation during tendon healing and identifies several multiscale properties that ma...Continue Reading

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Citations

Jul 10, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Andrey ZuskovLouis J Soslowsky
Apr 26, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yiwei LiMing Guo
Jun 12, 2019·Journal of Orthopaedic Surgery and Research·Andrzej SteplewskiAndrzej Fertala
Mar 18, 2020·Journal of Tissue Engineering and Regenerative Medicine·Francesca AtkinsonDeborah J Guest
Jul 20, 2018·Scientific Reports·Benjamin R FreedmanLouis J Soslowsky
Sep 30, 2020·Tissue Engineering. Part C, Methods·Ryan C LockeMegan L Killian
Nov 3, 2020·Soft Matter·Farid AlisafaeiVivek B Shenoy
Jan 24, 2021·Journal of Biomechanics·Hao XuZong-Ping Luo
Jul 30, 2021·Acta Biomaterialia·Patrick M WilliamsonAra Nazarian
Aug 9, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Eijiro MaedaTakeo Matsumoto
Dec 23, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Benjamin R FreedmanLouis J Soslowsky

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