Tendon Healing in Bone Tunnel after Human Anterior Cruciate Ligament Reconstruction: A Systematic Review of Histological Results

The Journal of Knee Surgery
Hongbin LuJin Qu

Abstract

Most studies concerning to tendon healing and incorporation into bone are mainly based on animal studies due to the invasive nature of the biopsy procedure. The evidence considering tendon graft healing to bone in humans is limited in several case series or case reports, and therefore, it is difficult to understand the healing process. A computerized search using relevant search terms was performed in the PubMed, EMBASE, Scopus, and Cochrane Library databases, as well as a manual search of reference lists. Searches were limited to studies that investigated tendon graft healing to bone by histologic examination after anterior cruciate ligament (ACL) reconstruction with hamstring. Ten studies were determined to be eligible for this systematic review. Thirty-seven cases were extracted from the included studies. Most studies showed that a fibrovascular interface would form at the tendon-bone interface at the early stage and a fibrous indirect interface with Sharpey-like fibers would be expected at the later stage. Cartilage-like tissue at tendon graft-bone interface was reported in three studies. Tendon graft failed to integrate with the surrounding bone in 10 of the 37 cases. Unexpectedly, suspensory type of fixation was used for ...Continue Reading

Citations

Jun 3, 2019·The American Journal of Sports Medicine·Cheng ZhengCan Chen
Apr 5, 2019·Current Reviews in Musculoskeletal Medicine·Michael D RiedigerOlufemi R Ayeni
Mar 17, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Fengyuan ZhaoYingfang Ao
Aug 13, 2021·Stem Cells International·Canlong WangWeiliang Shen
Aug 22, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xibang ZhaoJiali Wang

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