PMID: 11323533Apr 27, 2001Paper

Tendon healing stimulated by injected CDMP-2

Medicine and Science in Sports and Exercise
C Forslund, P Aspenberg

Abstract

Tendon healing stimulated by injected CDMP-2. Med. Sci. Sports Exerc., Vol. 33, No. 5, 2001, pp. 685-687. CDMP-2 is a member of the TFG-beta super-family. It is known to induce bone and cartilage formation but has also been shown under certain conditions to induce a tendon- and ligament-like tissue. The purpose of this study was to find possibilities for improvement of Achilles tendon repair during nonoperative treatment, by local injections of CDMP-2. Fifty rats had a 3-mm segment of the Achilles tendon removed. Six hours postoperatively, CDMP-2 was injected locally into the defect at a dose of 0, 2, 10, or 50 microg. Eight days after the operation, the rats were killed and the tensile strength of the repairing tendons was measured with a materials testing machine. After 8 d, the CDMP-2-treated tendons were 39% stronger than the controls (P = 0.0008). One single injection CDMP-2 can augment tendon repair. Mechanical stimulation is of great importance for tissue differentiation and tendon repair. The tendons in our model were mechanically loaded during healing and this might explain why CDMP-2 injections induced a strong tendon-like tissue instead of bone or cartilage in this model.

Citations

Apr 22, 2004·American Journal of Physical Medicine & Rehabilitation·Sunny R KimDenise I Campagnolo
Mar 4, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Borjana MikicDanielle Tsou
Sep 20, 2006·Journal of Biomedical Materials Research. Part a·Ichiro HaradaToshihiro Akaike
Jun 6, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Borjana MikicLouAnn Bierwert
Jun 23, 2009·Journal of Applied Physiology·Pernilla EliassonPer Aspenberg
Apr 7, 2010·Expert Opinion on Biological Therapy·Zi YinHong-Wei Ouyang
Oct 20, 2010·The American Journal of Sports Medicine·Lawrence V GulottaScott A Rodeo
May 7, 2011·Lasers in Medical Science·Jon JoensenJan Magnus Bjordal
Oct 1, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Guang YangRocky S Tuan
Sep 7, 2014·The American Journal of Sports Medicine·Joseph D LamplotLewis L Shi
Jul 7, 2005·Scandinavian Journal of Medicine & Science in Sports·O VirchenkoP Aspenberg
Jul 18, 2006·Foot & Ankle International·Brian C Toolan
Feb 3, 2007·Journal of Materials Science. Materials in Medicine·M A SuckowM C Hiles
Dec 11, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carina Forslund, Per Aspenberg
Jul 16, 2003·The American Journal of Sports Medicine·Carina Forslund, Per Aspenberg
May 7, 2011·Journal of Tissue Engineering and Regenerative Medicine·P P Y LuiK M Chan
Feb 4, 2011·Acta Orthopaedica. Supplementum·Sigbjørn Dimmen
Apr 17, 2003·Sports Medicine·Timothy MolloyGeorge Murrell
Jan 16, 2007·Journal of the American Podiatric Medical Association·Matthew B Werd
Mar 17, 2004·Acta Orthopaedica Scandinavica·Per Aspenberg, Olena Virchenko
Sep 12, 2018·Cells·Andrea Aparecida de AroEdson Rosa Pimentel
Feb 2, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Borjana MikicLouann Bierwert
Sep 27, 2003·Tissue Engineering·James Cho-Hong GohEng-Hin Lee
Nov 13, 2010·International Journal of Clinical Practice·R J Kampa, D A Connell
Jul 18, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Aiqun WeiAshish D Diwan
Feb 12, 2008·Clinical Orthopaedics and Related Research·David Kovacevic, Scott A Rodeo
Feb 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Borjana MikicLouann Bierwert
May 25, 2020·Bone·Maxim BezDan Gazit
Jul 19, 2002·Clinics in Podiatric Medicine and Surgery·Kent YingerLouis C Almekinders
May 14, 2005·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·Vishal Mehta, Daniel Mass

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