Tendon regeneration and repair with adipose derived stem cells

Current Stem Cell Research & Therapy
A Cagri Uysal, Hiroshi Mizuno

Abstract

Tendon, the crucial element of the musculoskeletal system, when damaged, never restores the biological and biomechanical properties completely. Recently, tissue engineering and regenerative medicine have enabled the differentiation of postnatal somatic stem cells or mesenchymal stem cells (MSCs) to different cell lineages and tissues including tendon. In addition, the MSCs, mainly bone marrow derived stem cells (BSCs) were proven to enhance tendon healing. Adipose derived stem cells (ASCs) were shown to be as effective as the other MSCs by their multipotency and proliferative efficiency. However, neither the differentiation of ASCs to tenocytes nor the tendon regeneration using ASCs have been described in literature. Recently, we have studied the effect of ASCs on primary tendon repair in in-vivo model. In this paper, we sought to discuss tendon tissue engineering by focusing on culture of tenocytes, biomaterials, scaffolds, mechanical loading, fibroblasts and mesenchymal stem cells and mainly on adipose derived stem cells. Tendon regeneration using ASCs might be one of the clinical remedies in near future. In addition, the enhancing effect of ASCs on tendon repair and tendon defects might enable better clinical outcomes in mus...Continue Reading

Citations

Jan 5, 2014·PloS One·Ana I GonçalvesManuela E Gomes
Sep 4, 2013·Regenerative Medicine·Benjamin M DaviesAndrew Carr
Oct 26, 2013·Cellular and Molecular Life Sciences : CMLS·Iain R MurrayBruno Péault
Feb 3, 2016·International Wound Journal·Naghmeh NaderiIain S Whitaker
Nov 26, 2015·Advanced Healthcare Materials·Ana I GonçalvesManuela E Gomes
Dec 30, 2014·Advanced Drug Delivery Reviews·Diana GasparDimitrios Zeugolis
Dec 3, 2014·Advanced Drug Delivery Reviews·Denitsa DochevaChristopher H Evans
Oct 6, 2016·Annals of the New York Academy of Sciences·Daniel J Leong, Hui B Sun
Jul 10, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Cagri A UysalHiroshi Mizuno
Oct 30, 2016·Physical Medicine and Rehabilitation Clinics of North America·Michael N BrownMichael Scarpone
Jan 30, 2014·Journal of Tissue Engineering and Regenerative Medicine·Carolyn HolladayDimitrios I Zeugolis
Nov 23, 2013·The Journal of Hand Surgery, European Volume·M G GalvezJ Chang
Apr 21, 2018·Tissue Engineering. Part C, Methods·Marco ViganòAlessandra Colombini
Jan 11, 2018·Connective Tissue Research·Letizia RinellaMaria Graziella Catalano
May 13, 2011·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Joseph J Albano, Robert W Alexander
Nov 20, 2016·BMC Musculoskeletal Disorders·Sherif ElniketyGordon W Blunn
Oct 10, 2020·World Journal of Stem Cells·Hao-Nan WangGuo-Xin Ni
Aug 13, 2021·Stem Cells International·Canlong WangWeiliang Shen
Jul 25, 2020·Current Stem Cell Research & Therapy·Niveditha KAnnie Abraham

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