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Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes

PloS One

Mar 25, 2014

Michael A DavidRobert A Mooney

Abstract

The obesity epidemic has resulted in a large increase in type 2 diabetes (T2D). While some secondary complications of T2D are well recognized and their cellular and molecular mechanisms are defined, the impact of T2D on the musculoskeletal system is less understood. Clinical evidence su...read more

Mentioned in this Paper

Metabolic Process, Cellular
Neuro-Oncological Ventral Antigen 2
Tendinopathy
Diabetes Mellitus, Non-Insulin-Dependent
Fat Necrosis
Salicylhydroxamic acid
Glycosaminoglycans
C57BL/6 Mouse
Fasting Blood Glucose Measurement
Murine
20
41
Paper Details
References
  • References38
  • Citations10
1234
  • References38
  • Citations10
1

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Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes

PloS One

Mar 25, 2014

Michael A DavidRobert A Mooney

PMID: 24658034

DOI: 10.1371/journal.pone.0091234

Abstract

The obesity epidemic has resulted in a large increase in type 2 diabetes (T2D). While some secondary complications of T2D are well recognized and their cellular and molecular mechanisms are defined, the impact of T2D on the musculoskeletal system is less understood. Clinical evidence su...read more

Mentioned in this Paper

Metabolic Process, Cellular
Neuro-Oncological Ventral Antigen 2
Tendinopathy
Diabetes Mellitus, Non-Insulin-Dependent
Fat Necrosis
Salicylhydroxamic acid
Glycosaminoglycans
C57BL/6 Mouse
Fasting Blood Glucose Measurement
Murine
20
41

Similar Papers Found In These Feeds

Obesity & CV Disease

Obesity is becoming a major health concern and epidemic worldwide. It is regarded as a systemic, low-grade inflammatory state and has been linked to several diseases, one of major importance is cardiovascular diseases. Here is the latest research on obesity and cardiovascular diseases.

Type 1 Diabetes

Type 1 diabetes is a chronic disease characterized by progressive immune-mediated destruction of insulin-producing beta cells in pancreatic islets. Here is the latest research.

Related Papers

The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons

Closed rupture of the tibialis anterior tendon: a report of 2 cases

The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle SurgeonsJuly 7, 2009
Felix NeumayerAlain Charles Masquelet
HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery

Novel treatment of a failed quadriceps tendon repair in a diabetic patient using a patella-quadriceps tendon allograft

HSS Journal : the Musculoskeletal Journal of Hospital for Special SurgeryJanuary 16, 2014
Sasha C Druskin, Scott A Rodeo
Paper Details
References
  • References38
  • Citations10
1234
  • References38
  • Citations10
1
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