Tenecteplase in acute lower-leg ischemia: efficacy, dose, and adverse events

Journal of Vascular and Interventional Radiology : JVIR
Jeffrey Eaton HullH Andy Park

Abstract

To prospectively evaluate tenecteplase (TNK) for thrombolysis in acute lower-limb ischemia. Forty-three consecutive limbs in 37 patients (15 male, 22 female) were treated for acute lower-limb ischemia. Group 1 included 22 limbs treated with TNK infusion of 0.25 mg/h and group 2 included 21 limbs treated with TNK at 0.125 mg/h. Technical success was defined by 95% clearing of thrombus, and clinical success was defined by Society of Interventional Radiology category for acute ischemia of +1. Complications were ranked by severity and relation to TNK administration. Logistic regression, Student t test, and analysis of variance were performed. TNK infusions averaged 24 hours in duration (SD, 13 h), with means of 20 hours in group 1 and 27 hours in group 2 (P = .071). Technical success was achieved in 84% of limbs (36 of 43): 82% in group 1 (18 of 22) and 86% in group 2 (18 of 21; P = .827). The SIR ischemia category improved (ie, +1) in 86% of limbs (37 of 43), stayed the same (ie, category 0) in 12% of limbs (five of 43), and worsened (ie, -1) in 2% of limbs (one of 43). TNK-related complications were seen in 12% of limbs (n = 5) and were correlated with percentage decrease in fibrinogen level, initial TNK bolus, and abciximab admi...Continue Reading

References

Mar 1, 1991·The Journal of Clinical Investigation·J I WeitzJ Ginsberg
Jul 1, 1995·Journal of Vascular and Interventional Radiology : JVIR·C J BeroG G Nicholas
Nov 1, 1995·Journal of Vascular and Interventional Radiology : JVIR·J I Weitz
Oct 6, 1997·Journal of Vascular Surgery·R B RutherfordD N Jones
Mar 29, 2000·Journal of Vascular and Interventional Radiology : JVIR·M M DavidianG Zemel
Aug 6, 2000·Journal of Vascular and Interventional Radiology : JVIR·K OurielD Gibbens
Aug 11, 2000·The American Journal of Medicine·M Verstraete
May 8, 2001·Journal of Vascular and Interventional Radiology : JVIR·N PatelUNKNOWN Technology Assessment Committee of the Society of Cardiovascular & Interventioanal Radiology
Jan 15, 2002·Journal of Vascular and Interventional Radiology : JVIR·Peter DrescherWilliam S Rilling
Jun 18, 2002·The European Respiratory Journal. Supplement·S Z Goldhaber
Oct 3, 2002·Thrombosis Research·Vincenzo Costantini, Massimo Lenti
Nov 13, 2002·Journal of Vascular and Interventional Radiology : JVIR·David J BurkartStephanie R Thurlo
Nov 15, 2002·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Mahmood K RazaviMichael D Dake
Apr 22, 2003·AJR. American Journal of Roentgenology·Peter DrescherMartin R Crain
Jun 21, 2003·Journal of Vascular and Interventional Radiology : JVIR·David J BurkartStephanie R Thurlo
Mar 19, 2004·Journal of Vascular and Interventional Radiology : JVIR·Kenneth OurielStephan Duda
Jun 5, 2004·Journal of Vascular and Interventional Radiology : JVIR·Jeffrey Eaton HullJames A Urso
Aug 10, 2004·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·David E AllieCraig M Walker
Nov 24, 2004·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·David E AllieCraig M Walker

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Citations

Sep 1, 2006·Seminars in Interventional Radiology·Harry L Morrison
Jun 7, 2011·The American Journal of the Medical Sciences·Zehra JafferyChristopher J White
Jul 27, 2010·Journal of Vascular and Interventional Radiology : JVIR·Rodney D Raabe
Aug 3, 2007·Thrombosis Research·Kosmas I ParaskevasDimitri P Mikhailidis
Jun 16, 2015·Seminars in Vascular Surgery·Reagan L Ross, Adam W Beck
Jan 4, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Martin BjörckKumud Rai
Aug 7, 2019·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Bernard S LeenstraGert Jan de Borst

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