Tenidap decreases IL-8 and monocyte chemotactic peptide-1 (MCP-1) mRNA expression in the synovial tissue of rabbits with antigen arthritis and in cultured synovial cells

Clinical and Experimental Immunology
I PalaciosG Herrero-Beaumont

Abstract

Since IL-8 and MCP-1 are chemoattractant proteins that participate in the recruitment of inflammatory cells into the arthritic joint, we examined the effects of tenidap, a new anti-inflammatory drug of the oxindole family, on IL-8 and MCP-1 expression in the joints of rabbits with acute antigen arthritis. The model was induced by injecting 5 mg/ml ovalbumin into the knees of 20 preimmunized rabbits. Animals were randomized into two groups: treated with tenidap (15 mg/kg per 12 h), or untreated. The effect of tenidap treatment was evaluated on chemokine production in synovial membranes of rabbits with arthritis and in cultured monocytic and synovial cells (SC). By immunoperoxidase staining, chemokines were localized in the synovial tissue. Chemokine messenger RNA levels in the synovial membranes and in cultured cells were analysed by reverse transcription-polymerase chain reaction (RT-PCR). At the end of the study, tenidap significantly reduced neutrophil infiltration into the joint cavity (27+/-4 x 10(6) cells/ml versus 45+/-6 x 10(6) cells/ml in untreated; P<0.05), and synovial effusion (134+/-15 microl versus 236+/-19 microl in untreated; P<0.005). Untreated rabbits showed synovial membrane up-regulation in mRNA expression of...Continue Reading

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Citations

Aug 13, 2011·Viral Immunology·Itta Krishna ChaaitanyaPaluru Vijayachari
Jun 10, 2008·British Journal of Pharmacology·G Herrero-BeaumontR Largo
Sep 29, 2004·Respiratory Physiology & Neurobiology·Fabienne BrégeonYves Jammes
Apr 20, 2010·Osteoarthritis and Cartilage·R LargoG Herrero-Beaumont
Jan 31, 2003·Expert Opinion on Therapeutic Targets·Janet DawsonChristoph Wiessner
Apr 21, 2016·The Cochrane Database of Systematic Reviews·Devashana GuptaVicki Nisenblat
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naim ShehadehNathan Karin
Mar 30, 2013·Human Reproduction Update·Fernando M ReisRobert N Taylor
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·D HornungR N Taylor
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patricia L PodolinHenry M Sarau
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·V M CorrigallG S Panayi

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