Tenofovir Alafenamide Fumarate Therapy for HIV Treatment: Cardiometabolic and Renal Safety.

AIDS Research and Human Retroviruses
Vasilis PetrakisDimitrios Papazoglou

Abstract

Antiretroviral treatment based on tenofovir alafenamide fumarate (TAF) is increasingly recommended, as it maintains the viral suppression and improves renal function and bone density in comparison with tenofovir disoproxil fumarate (TDF). We carried out a retrospective cohort study including experienced patients who switched treatment from TDF to TAF. Serum lipids and glucose, renal function, body mass index (BMI), and cardiovascular risk were evaluated before and 3 and 6 months after the initiation of TAF-based treatment. We identified 85 patients on TAF-based treatment. The majority were men (82.9%), smokers (70%), and older than 40 years. Significant increases in lipids and BMI were noted, but cardiovascular risk remained <7.5%. Renal function remained normal with a notable improvement among patients with renal impairment. These results suggest that TAF has no significant effect on glucose and does not meaningfully increase cardiovascular risk, despite an elevation in serum lipids. It also exhibits renal safety. However, the increase of BMI was significant. Further studies are needed to confirm these findings in larger patient series and over longer follow-up periods.

References

Aug 8, 1998·The New England Journal of Medicine·S H MichaelsP Kissinger
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·David VerhelstJerome Rossert
Jan 6, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Renslow Sherer
Apr 3, 2009·The New England Journal of Medicine·Mari M KitahataUNKNOWN NA-ACCORD Investigators
Jun 18, 2009·AIDS·Birgit GrundUNKNOWN INSIGHT SMART Body Composition Substudy Group
Jul 20, 2011·The New England Journal of Medicine·Myron S CohenUNKNOWN HPTN 052 Study Team
Apr 5, 2013·Pharmacotherapy·Jason J SchaferKathleen E Squires
Jun 19, 2013·PloS One·Philippe MorlatUNKNOWN Groupe D’epidémiologie Clinique du Sida en Aquitaine (Gecsa)
Jun 29, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Peter J RuaneKitty Yale
May 30, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Paul E SaxScott McCallister
Jul 8, 2015·Antimicrobial Agents and Chemotherapy·Nicolas A MargotChristian Callebaut
Oct 28, 2015·Antimicrobial Agents and Chemotherapy·Gabriel BirkusTomas Cihlar
Nov 30, 2016·The Annals of Pharmacotherapy·Jamielynn C Sebaaly, Denise Kelley
Aug 7, 2017·Trends in Cardiovascular Medicine·Flavia BalloccaFiorenzo Gaita
Sep 19, 2018·Therapeutic Advances in Infectious Disease·Nomvuyo Z MothobiDeborah J Marriott

❮ Previous
Next ❯

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.