Tenofovir-Associated Bone Adverse Outcomes among a US National Historical Cohort of HIV-Infected Veterans: Risk Modification by Concomitant Antiretrovirals

Infectious Diseases and Therapy
Joanne LaFleurStephen Esker

Abstract

Tenofovir disoproxil fumarate (TDF) has been associated with greater incidences of bone complications, which might be modified by some concomitantly administered antiretrovirals, possibly by their effect on tenofovir concentrations. We compared bone adverse outcomes among treatment-naïve HIV-infected US veterans initiating efavirenz (EFV)-containing TDF/emtricitabine (FTC) regimens versus those initiating non-EFV-containing TDF/FTC regimens. Using national Veterans Health Administration clinical and administrative data sets, we identified a cohort of treatment-naïve HIV-infected veterans without bone disease who initiated therapy with TDF/FTC plus EFV, rilpivirine, elvitegravir/cobicistat, or ritonavir-boosted protease inhibitors in 2003-2015. The primary composite adverse bone outcome was the unadjusted incidence rate (IR) of osteoporosis, osteopenia, or fragility fracture (any hip, wrist, or spine fracture). To account for selection bias and confounding, we used inverse probability of treatment-weighted Cox proportional hazards regression models to calculate adjusted hazard ratios (HRs) for each outcome associated with EFV + TDF/FTC versus each non-EFV-containing TDF/FTC regimen. Of 33,048 HIV-positive veterans, 7161 initiate...Continue Reading

References

Aug 24, 2000·Epidemiology·J M RobinsB Brumback
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anthony E ZimmermannGregory Braden
Jan 16, 2008·AIDS·Charles CazanaveUNKNOWN Groupe d'Epidémiologie Clinique du SIDA en Aquitaine
Jul 3, 2008·The Journal of Clinical Endocrinology and Metabolism·Virginia A TriantSteven K Grinspoon
Jun 18, 2009·AIDS·Birgit GrundUNKNOWN INSIGHT SMART Body Composition Substudy Group
Sep 11, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hans-Jürgen StellbrinkUNKNOWN ASSERT Study Group
Feb 16, 2011·Annals of Internal Medicine·Eric S DaarUNKNOWN AIDS Clinical Trials Group Study A5202 Team
Mar 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin YoungUNKNOWN HIV Outpatient Study (HOPS) Investigators
Apr 28, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michelle K YongJennifer F Hoy
Jun 27, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Polina GermanAnita Mathias
Sep 7, 2012·AIDS·Michael T YinGrace A McComsey
Sep 25, 2012·Current Osteoporosis Reports·Monique J Brown, Briana Mezuk
Jun 29, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Peter J RuaneKitty Yale
Sep 30, 2014·AIDS·Aoife G CotterUNKNOWN HIV UPBEAT Study Group
Jun 16, 2015·Annals of Internal Medicine·Edgar Turner OvertonMichael T Yin
May 20, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ighovwerha OfotokunM Neale Weitzmann

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

IPTW
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.