Tenofovir disoproxil fumarate is superior to lamivudine plus adefovir in lamivudine-resistant chronic hepatitis B patients

World Journal of Gastroenterology : WJG
Dan-Hong YangHai-Jun Huang

Abstract

To assess the efficacy of tenofovir disoproxil fumarate (TDF) in lamivudine (LAM)-resistant patients with a suboptimal response to LAM plus adefovir (ADV). We retrospectively analyzed the efficacy of switching to tenofovir disoproxil fumarate in suboptimal responders to lamivudine plus adefovir. Charts were reviewed for LAM-resistant chronic hepatitis B (CHB) patients who visited the Zhejiang Province People's Hospital and The First Affiliated Hospital, College of Medicine, Zhejiang University, from June 2009 to May 2013. Patients whose serum hepatitis B virus (HBV) DNA remained detectable despite at least 6 mo of LAM plus ADV combination therapy were included. Patients with a suboptimal response to LAM plus ADV were randomized to switch to TDF monotherapy (300 mg/d orally; TDF group) or to continuation with LAM (100 mg/d orally) plus ADV (10 mg/d orally; LAM plus ADV group) and were followed for 48 wk. Serum HBV DNA was determined at baseline and weeks 4, 12, 24, 36, and 48. HBV serological markers and biochemistry were assessed at baseline and weeks 12, 24, and 48. Resistance surveillance and side effects were monitored during therapy. Fifty-nine patient were randomized to switch to TDF (n = 28) or continuation with LAM plus ...Continue Reading

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Mar 31, 2016·Hepatology International·Akinobu TawadaOsamu Yokosuka
Dec 2, 2015·Clinics and Research in Hepatology and Gastroenterology·Hui-Lian WangQilan Ning
Aug 20, 2016·Gut and Liver·Eun Young ChoUNKNOWN Antiviral Resistance Study Group
Nov 21, 2017·World Journal of Gastroenterology : WJG·Manuel RodríguezUNKNOWN TENOSIMP-B Research Group
Aug 14, 2021·Revista de gastroenterología de México·F Higuera-de-la-TijeraE Wolpert-Barraza

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