PMID: 12773076May 30, 2003Paper

Tenofovir disoproxil fumarate

The Annals of Pharmacotherapy
Shellee A Grim, Frank Romanelli

Abstract

To review the pharmacology, virology, pharmacokinetics, efficacy, safety, resistance profile, and clinical use of tenofovir disoproxil fumarate. A MEDLINE search was performed (1966-August 2002) using the following terms: tenofovir, tenofovir disoproxil fumarate, PMPA (9-(R)-[2-(phosphonomethoxy)propyl]adenine), and Viread. Abstracts from HIV-related meetings were reviewed. DATA EXTRACTION AND STUDY SELECTION: Publications and meeting abstracts regarding tenofovir were reviewed. The most recent and pertinent items were included. Tenofovir disoproxil fumarate is a nucleotide prodrug that is diphosphorylated to its active moiety, tenofovir diphosphate. In this form, tenofovir acts as a reverse transcriptase inhibitor to inhibit HIV-1 replication. In clinical trials, tenofovir was effective at suppressing HIV-1 RNA and boosting CD4+ cell counts. Tenofovir has a long intracellular half-life, which permits once-daily dosing. Since tenofovir does not interact with the cytochrome P450 pathway, it exhibits minimal drug interactions, with the exception of didanosine. Compared with other reverse transcriptase inhibitors, tenofovir may have advantages in terms of toxicity and medication adherence profiles. Ongoing studies are also analyzi...Continue Reading

References

May 1, 1995·Nature Medicine·W Lewis, M C Dalakas
May 3, 1997·Lancet·R S HoggJ S Montaner
Mar 7, 2000·Journal of the American Society of Nephrology : JASN·Edmund S HoTomas Cihlar
May 1, 2001·Bioorganic & Medicinal Chemistry Letters·C BallatoreJ Balzarini
Jul 27, 2001·The Journal of Infectious Diseases·K K Van RompayM L Marthas
Aug 14, 2001·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M Peeters
Sep 21, 2001·Nucleosides, Nucleotides & Nucleic Acids·M D MillerV Miller
Nov 15, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·S G DeeksD F Coakley
Mar 2, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Alice F TarantalR Bruce Martin
Jul 4, 2002·JAMA : the Journal of the American Medical Association·Patrick G YeniPaul A Volberding
Jul 19, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·J van GelderP Augustijns
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Florian van BömmelThomas Berg

❮ Previous
Next ❯

Citations

Dec 5, 2006·Expert Review of Anti-infective Therapy·Carlos J MontoyaAlan L Landay
Nov 26, 2011·BMC Research Notes·Hadija H Semvua, Gibson S Kibiki
Apr 16, 2020·Pharmaceutics·Hannes LengauerZdenko Časar
Jul 5, 2003·The Annals of Pharmacotherapy·Roman J Nestor
Dec 18, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Helen BygraveKatharina Kranzer
Oct 2, 2009·Pharmacotherapy·Alice M JenhPaul A Pham
Jan 25, 2008·Journal of Virology·Ivona PandreaCristian Apetrei
Aug 30, 2012·Expert Review of Gastroenterology & Hepatology·Maria Buti, Maria Homs
Aug 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Peter J Piliero
Jul 26, 2006·Pharmacotherapy·Frank J Piacenti
May 16, 2017·Pharmaceutical Development and Technology·Selin Seda TimurSema Çalış
Oct 28, 2015·Antimicrobial Agents and Chemotherapy·Gabriel BirkusTomas Cihlar
Oct 14, 2004·The Annals of Pharmacotherapy·Peter L Anderson
Dec 7, 2007·The Lancet Infectious Diseases·George V PapatheodoridisAthanasios J Archimandritis
Oct 4, 2011·Mayo Clinic Proceedings·Raymund R Razonable

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Ryan D CooperMarcello Tonelli
Journal of Hepatology
Daniel Shouval
Expert Opinion on Drug Metabolism & Toxicology
Paul A Pham, Joel E Gallant
© 2022 Meta ULC. All rights reserved