Tenofovir: quo vadis anno 2012 (where is it going in the year 2012)?

Medicinal Research Reviews
Erik De Clercq

Abstract

Twenty years after its original discovery, tenofovir has acquired a crucial position in the fight against human immunodeficiency virus (HIV). First, tenofovir disoproxil fumarate (TDF) is not only efficacious against, and has been licensed for the treatment of HIV (AIDS), but also HBV (hepatitis B). Second, for the treatment of HIV infections, TDF can be used in combination with other anti-HIV drugs, such as emtricitabine (combination termed Truvada(®)) and Truvada can be further combined with efavirenz, rilpivirine, elvitegravir, atazanavir, or darunavir, as a single once-daily oral pill. Third, Truvada can be used prophylactically to prevent transmission of HIV infection. And fourth, to prevent sexual HIV transmission, tenofovir could also be used topically (i.e., as a vaginal gel).

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Citations

Jul 24, 2013·Biochemical Pharmacology·Erik De Clercq
Mar 8, 2014·BMC Infectious Diseases·Davide MangioniAndrea Gori
Apr 10, 2013·Medicinal Research Reviews·Erik De Clercq
Mar 16, 2013·Medicinal Research Reviews·Erik De Clercq
Aug 1, 2012·Current Opinion in Virology·Erik De Clercq
Dec 29, 2012·Biochemical Pharmacology·Erik De Clercq
Sep 18, 2012·Critical Reviews in Microbiology·Derrick LouzRob C Hoeben
Jun 10, 2016·Clinical Microbiology Reviews·Erik De Clercq, Guangdi Li

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