Tenofovir rescue therapy in pregnant females with chronic hepatitis B

World Journal of Gastroenterology : WJG
Yu-Hong HuHao-Dong Cai

Abstract

To evaluate the safety and efficacy of tenofovir monotherapy in pregnant females resistant to lamivudine or telbivudine. The effect of tenofovir on the fetus was also assessed. The clinical data of 17 females were reviewed in this study. Adverse events and pregnancy outcomes from January 1, 2011 to June 30, 2013 were evaluated in the Department of Gynecology and Obstetrics of Beijing Ditan Hospital, Capital Medical University, Beijing, China. These pregnant females developed lamivudine (LAM)- or telbivudine (LdT)-resistant chronic hepatitis B and received tenofovir (TDF) therapy (300 mg/d), and its curative effect, maternal and perinatal adverse events, fetal growth and development, and neonatal prognosis were evaluated. The median hepatitis B virus (HBV) DNA level in the pregnant females with LAM or LdT resistance was 5.9 (range, 4.2-7.2) log10 copies/mL before the initiation of TDF. Ten of these females had abnormal alanine aminotransferase (ALT) levels. The patients were treated with TDF for a median of 24 wk (range, 12-40 wk). Fourteen females (82.4%) had an HBV DNA level of <500 copies/mL at the time of delivery. This decrease was statistically significant (P<0.0001). Serum ALT levels were normalized in all subjects with a...Continue Reading

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Citations

Mar 7, 2017·World Journal of Hepatology·Bircan Kayaaslan, Rahmet Guner
Oct 13, 2018·World Journal of Hepatology·Alberto Enrico MaraoloGuglielmo Borgia
Oct 1, 2020·Obstetrical & Gynecological Survey·Sirinart Sirilert, Theera Tongsong
Oct 14, 2020·Nature Reviews. Gastroenterology & Hepatology·Norah A TerraultGonzague Jourdain
Jan 3, 2020·European Journal of Gastroenterology & Hepatology·Xuesong GaoWei Yi
Apr 7, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Ka Wang Cheung, Terence Tzu-Hsi Lao
Sep 14, 2021·American Journal of Obstetrics and Gynecology·Jodie Dionne-OdomAlan T N Tita

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