Tenoxicam concentrations in synovium and joint cartilage in humans

Agents and Actions
B BannwarthA Gaucher

Abstract

Tenoxicam is an NSAID of the oxicam group. Its distribution in articular tissues was investigated in 12 patients who required total arthroplasty of the hip. They were given tenoxicam 20 mg once daily for 8 to 30 days before surgery. Blood, synovium and cartilage samples were taken concurrently during surgery, about 14 hours after the last tenoxicam dose. The tissues were ground using a freeze grinder. Tenoxicam was assayed by HPLC. Tenoxicam concentrations averaged 6.21 +/- 3.81 micrograms/ml in plasma, 7.56 +/- 4.67 micrograms/g in synovium and 2.05 +/- 1.43 micrograms/g in cartilage. The individual synovium/cartilage ratios ranged from 1.9 to 9.7. Finally tenoxicam exhibited more affinity for its target organ (synovial tissue) than for joint cartilage.

References

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Citations

Aug 12, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S T ColbertM McCarroll
Jan 1, 1993·Annals of the Rheumatic Diseases·B BannwarthJ Dehais
Oct 16, 2001·Journal of Pharmaceutical and Biomedical Analysis·F LagrangeB Bannwarth
Feb 29, 2008·Journal of Pharmaceutical Sciences·Claus LarsenPia H Andersen
Jan 6, 2015·International Orthopaedics·Roger JawishAli Chameseddine
Dec 21, 2002·Best Practice & Research. Clinical Anaesthesiology·Narinder Rawal

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