Tenoxicam i.v. in major gynaecological surgery--pharmacokinetic, pain relief and haematological effects

Anaesthesia and Intensive Care
R D JonesS K Lo

Abstract

This study compared postoperative analgesic dispensation and measures relating to haemostasis following intravenous administration, in a randomized double-blinded manner, of either placebo or tenoxicam 20 mg to 30 women presenting for major gynaecological oncology surgery under a standardized, combined epidural/general anaesthetic technique. Pharmacokinetic disposition of tenoxicam in this patient cohort was also described. There was no objective or subjective alteration in haemostatic function or increase in blood loss, nor any deviation from the normal range of values. Postoperative analgesia during the first 48 hours was delivered to achieve a VAS endpoint of less than five on leg-raising, by a combination of a nurse-controlled low-dose background epidural infusion and patient-administered epidural bolus. Greater VAS variability was observed during the first four postoperative hours (P = 0.08). The tenoxicam group self-administered significantly fewer epidural bolus doses to maintain satisfactory analgesia compared with the placebo group during the first 24 hours (P = 0.004) and 48 hours (P = 0.01) postoperatively. Similar differences between the groups in the total dose of the epidural bupivacaine/fentanyl mixture delivered...Continue Reading

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Citations

Dec 18, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W A Prado, R M C Pontes
Mar 8, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M ErbaşM Turgut Alper Ozkan
Mar 15, 2005·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Tamer AkcaSuha Aydin

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