PMID: 22572232May 11, 2012Paper

Tensile strength of human pericardium treated with glutaraldehyde

Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
Hiromasa YamashitaMitsuo Umezu

Abstract

We have reconstructed aortic valves using autologous pericardium treated with glutaraldehyde since April 2007. However, the strength of the human pericardium has not been confirmed. We compared tensile strength between glutaraldehyde-treated human pericardium and aortic valve leaflets with various degrees of calcification to determine their suitability for use in aortic valve reconstruction. We measured the ultimate tensile strength and elasticity of samples of glutaraldehyde-treated pericardia (n = 8), non-calcified (n = 12), calcified (n = 9) and decalcified (n = 21) aortic leaflets collected from 23 patients who underwent aortic valve surgery. Aortic valves were decalcified using a cavitational ultrasonic surgical aspirator. The pericardium was immersed in 0.6% buffered glutaraldehyde for 10 minutes and then rinsed three times for 6 minutes each in normal saline. The ultimate tensile strength of the glutaraldehyde-treated human pericardium, non-calcified, calcified and decalcified leaflets was 10, 2.8, 1.0 and 0.8 MPa, respectively. The ultimate tensile strength of glutaraldehyde-treated human pericardium was 4 times higher than non-calcified leaflets, indicating its suitability for application to aortic valve reconstruction...Continue Reading

References

Jan 1, 1996·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·H J KellnerE Struck
Jul 26, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Zohair Al HaleesCarlos Duran
May 6, 2008·The Journal of Thoracic and Cardiovascular Surgery·Shun KohsakaStephanie A Coulter
Nov 22, 2008·The Annals of Thoracic Surgery·Mariano VicchioMaurizio Cotrufo
Jan 29, 2011·Interactive Cardiovascular and Thoracic Surgery·Shigeyuki OzakiSo Hagiwara
Apr 29, 2011·The Annals of Thoracic Surgery·Isamu KawaseSo Hagiwara

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Citations

Feb 22, 2013·Interactive Cardiovascular and Thoracic Surgery·Isamu KawaseSo Hagiwara
Dec 12, 2012·The Journal of Thoracic and Cardiovascular Surgery·Shigeyuki OzakiSo Hagiwara
Mar 27, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Rosaria SantoroMaurizio Pesce
Oct 23, 2015·Interactive Cardiovascular and Thoracic Surgery·Paola AguiariAndrea Bagno
Feb 19, 2019·ESC Heart Failure·Masato MakinoYoshitsugu Nakamura
May 28, 2016·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hiromasa Yamashita, Shigeyuki Ozaki
Mar 20, 2018·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Susumu IsodaMunetaka Masuda
Oct 20, 2020·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Tomoya InoueHitoshi Yaku
Feb 5, 2021·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Luca KoechlinOliver Reuthebuch
Feb 6, 2021·Interactive Cardiovascular and Thoracic Surgery·Takayuki KawashimaShinji Miyamoto

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