Tension generation and increase in voltage-activated Na+ current by crotamine

European Journal of Pharmacology
A C MatavelJ S Cruz

Abstract

We performed the present experiments to study the action of crotamine, a toxin isolated from the venom of the South American rattlesnake, Crotalus durissus terrificus, on macroscopic Na+ currents in frog skeletal muscle by using the loose patch clamp technique. Crotamine at 50 microM increased the peak Na+ current by 50% (P < 0.05). In addition, the voltage dependence of inactivation was shifted by +8 mV. Other parameters of Na+ currents (reversal potential, voltage-dependence of activation and time courses of inactivation, of activation and of removal of inactivation) were not significantly affected. We suggest that crotamine inhibits the direct transition of channels from closed to inactivated states, thereby forcing their transition through the open states.

References

Nov 1, 1977·The Journal of General Physiology·F Bezanilla, C M Armstrong
Jan 1, 1978·Toxicon : Official Journal of the International Society on Toxinology·N MaedaF E Russell
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·L A Smith, J J Schmidt
Jul 1, 1989·British Journal of Pharmacology·S J Hong, C C Chang
Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·C L OwnbyI I Kaiser
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·A L BieberR R Becker
Jul 1, 1971·Toxicon : Official Journal of the International Society on Toxinology·J CheymolM Roch-Arveiller
Jul 1, 1971·Toxicon : Official Journal of the International Society on Toxinology·J CheymolM Roch-Arveiller
Oct 1, 1984·The Journal of General Physiology·C A Vandenberg, R Horn
Jan 1, 1983·Toxicon : Official Journal of the International Society on Toxinology·S J Hong, C C Chang
Jan 1, 1995·Annual Review of Physiology·R L Barchi
Sep 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·O V Brazil, M D Fontana
Feb 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·D A AraújoP S Beirão
Aug 1, 1995·Canadian Journal of Physiology and Pharmacology·M OhkuraY Ohizumi
Apr 1, 1952·The Journal of Physiology·A L HODGKIN, A F HUXLEY

❮ Previous
Next ❯

Citations

Nov 4, 2010·Cellular and Molecular Neurobiology·Carlos Manlio Diaz-GarciaMarcia Hiriart
Dec 12, 2001·Toxicon : Official Journal of the International Society on Toxinology·Steven D Aird
Mar 13, 2002·Journal of Molecular Graphics & Modelling·A M SiqueiraB Maigret
Apr 24, 2003·European Journal of Biochemistry·Giuseppe NicastroAlberto Spisni
Oct 17, 2013·PLoS Neglected Tropical Diseases·Udaya K RanawakaH Janaka de Silva
May 13, 2014·Toxicon : Official Journal of the International Society on Toxinology·Liane S VargasPâmela B Mello-Carpes
Jun 26, 2007·Toxicon : Official Journal of the International Society on Toxinology·Carina T RizziLanfranco R P Troncone
Oct 27, 2004·Toxicon : Official Journal of the International Society on Toxinology·Allan M Torres, Philip W Kuchel
Jul 31, 2004·Toxicon : Official Journal of the International Society on Toxinology·G Rádis-BaptistaT Yamane
Aug 22, 2006·Toxicon : Official Journal of the International Society on Toxinology·M Boni-MitakeJ R Rogero
Aug 24, 2005·Toxicon : Official Journal of the International Society on Toxinology·N OguiuraG Rádis-Baptista
Dec 3, 2014·Toxicon : Official Journal of the International Society on Toxinology·Thu Trang Thi VuHan Choe
Dec 23, 2017·Toxins·Paola G OjedaWendy González
Mar 6, 2013·Muscle & Nerve·Saraguaci Hernandez-Oliveira e SilvaLéa Rodrigues-Simioni
Sep 6, 2012·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Mônika A CoronadoChristian Betzel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.