PMID: 16522262Mar 9, 2006Paper

Tension-type headache

Current Neurology and Neuroscience Reports
Ninan T Mathew

Abstract

Tension-type headache, the most common type of primary headache disorder, is reclassified in the second International Headache Society classification with clear diagnostic criteria. Chronic tension-type headache (CTTH) differs from episodic form in frequency, lack of response to most treatment strategies, more medication overuse, and more loss of quality of life. New concepts in the pathophysiology of CTTH emphasize the possible role of central nociceptive pathway sensitization in addition to peripheral myogenic factors. Mechanisms of central sensitization, even though poorly understood, may involve nitric oxide system and N-methyl-D-aspartate receptors. Future treatment modalities are likely to be based on such mechanisms. Using MRI and voxel-based morphometry, structural abnormalities have been found in patients with CTTH for the first time. Pain processing areas such as dorsal rostral and ventral pons, anterior cingulate cortex, anterior and posterior insular cortex, right posterior temporal lobe, orbitofrontal cortex, para hippocampus bilaterally, and the right cerebellum were found to have decreased gray matter in patients with CTTH compared with control subjects and patients with medication overuse headache. Amitriptyline...Continue Reading

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Citations

Jul 8, 2011·Current Pain and Headache Reports·Lars Bendtsen, César Fernández-de-la-Peñas
Sep 2, 2008·Brain : a Journal of Neurology·L BuchgreitzL Bendtsen
Nov 26, 2008·The Journal of Headache and Pain·Sherif M HamdyRasha Hasan
Feb 18, 2009·Cephalalgia : an International Journal of Headache·K Lindelof, L Bendtsen
Jul 7, 2015·European Journal of Pain : EJP·L BendtsenT J Steiner
Oct 25, 2006·Cephalalgia : an International Journal of Headache·E SöderbergE Stener-Victorin
Sep 30, 2010·Cephalalgia : an International Journal of Headache·Stuart CathcartPaul Rolan
Mar 19, 2008·Expert Review of Neurotherapeutics·Giuseppe NappiGiorgio Sandrini
Oct 30, 2010·Headache·David BezovLars Bendtsen
Jul 5, 2007·American Journal of Physical Medicine & Rehabilitation·Tracy DePuyMartin K Childers
Mar 18, 2009·Neurologic Clinics·Lars Bendtsen, Rigmor Jensen

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