Tensional homeostasis at different length scales.

Soft Matter
Dimitrije Stamenović, Michael L Smith

Abstract

Tensional homeostasis is a phenomenon of fundamental importance in mechanobiology. It refers to the ability of organs, tissues, and cells to respond to external disturbances by maintaining a homeostatic (set point) level of mechanical stress (tension). It is well documented that breakdown in tensional homeostasis is the hallmark of progression of diseases, including cancer and atherosclerosis. In this review, we surveyed quantitative studies of tensional homeostasis with the goal of providing characterization of this phenomenon across a broad range of length scales, from the organ level to the subcellular level. We considered both static and dynamics approaches that have been used in studies of this phenomenon. Results that we found in the literature and that we obtained from our own investigations suggest that tensional homeostasis is an emergent phenomenon driven by collective rheostatic mechanisms associated with focal adhesions, and by a collective action of cells in multicellular forms, whose impact on tensional homeostasis is cell type-dependent and cell microenvironment-dependent. Additionally, the finding that cadherins, adhesion molecules that are important for formation of cell-cell junctions, promote tensional homeos...Continue Reading

References

Nov 1, 1991·The Journal of Investigative Dermatology·P DelvoyeC M Lapière
Apr 1, 1989·The American Journal of Physiology·B L LangilleF W Keeley
Jan 1, 1967·Circulation Research·H Wolinsky, S Glagov
Oct 1, 1970·Circulation Research·H Wolinsky
May 1, 1995·Journal of Biomechanics·H C Han, Y C Fung
Jun 1, 1994·Journal of Applied Physiology·B SukiK R Lutchen
Jan 1, 1994·Eye·H C ChenE M Kohner
Jul 1, 1995·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·A J BanesL Miller
Mar 30, 1999·Biophysical Journal·M Dembo, Y L Wang
Jun 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·I M BayerB L Langille
Oct 3, 2001·Physical Review Letters·B FabryJ J Fredberg
Feb 8, 2002·American Journal of Physiology. Cell Physiology·James P ButlerJeffrey J Fredberg
Feb 8, 2002·American Journal of Physiology. Cell Physiology·Ning WangDimitrije Stamenović
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John L TanChristopher S Chen
Apr 13, 2004·Molecular Biology of the Cell·Celeste M NelsonChristopher S Chen
Jul 23, 2004·Physiological Reviews·Gianfranco Bazzoni, Elisabetta Dejana
Oct 20, 2004·Cell Motility and the Cytoskeleton·Takeomi MizutaniKazushige Kawabata
Jun 7, 2005·Nature Materials·Predrag BursacJeffrey J Fredberg
Sep 20, 2005·Cancer Cell·Matthew J PaszekValerie M Weaver
Oct 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Roland KaunasShu Chien
Jan 13, 2006·The Journal of Cell Biology·Jérôme M GoffinBoris Hinz
Apr 4, 2006·Cellular Signalling·Roland KaunasShu Chien
Jul 18, 2006·Nature Materials·Linhong DengJeffrey J Fredberg
Jul 20, 2006·Journal of the Royal Society, Interface·G LenormandJ J Fredberg
Oct 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kyle KurpinskiSong Li
Nov 14, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Shu Chien
Dec 8, 2006·Annals of Biomedical Engineering·Noah RosenblattDimitrije Stamenović
Jun 1, 2007·Nature·Xavier TrepatJeffrey J Fredberg
Jun 6, 2008·Journal of Biomechanical Engineering·Zhensong WeiAnthony G Evans
Aug 30, 2008·Cellular and Molecular Life Sciences : CMLS·F van Roy, G Berx
Oct 15, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Rumi De, Samuel A Safran
Dec 17, 2008·Science·Clarence E Chan, David J Odde
Jan 24, 2009·Nature Reviews. Cancer·Darci T ButcherValerie M Weaver
Apr 30, 2009·Annual Review of Biomedical Engineering·Brenton D Hoffman, John C Crocker
Dec 4, 2009·Journal of Biomechanics·S NicolleJ-F Palierne
Apr 9, 2010·Cellular and Molecular Bioengineering·Dimitrije StamenovićBéla Suki
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Venkat MaruthamuthuMargaret L Gardel

❮ Previous
Next ❯

Citations

Mar 9, 2021·Biomechanics and Modeling in Mechanobiology·Jonas F EichingerChristian J Cyron
Oct 6, 2021·ACS Biomaterials Science & Engineering·Younghoon KwonMegan T Valentine

❮ Previous
Next ❯

Methods Mentioned

BETA
rheology

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Cellular and Molecular Bioengineering
Alicia J ZollingerMichael L Smith
American Journal of Physiology. Cell Physiology
Elizabeth P CanovićDimitrije Stamenović
International Journal for Numerical Methods in Biomedical Engineering
Sze Nok TamDimitrije Stamenović
Hellenis adelphe
A Demetriados
Biophysical Journal
Kevin D WebsterDaniel A Fletcher
© 2021 Meta ULC. All rights reserved