Teprotumumab: First Approval

Drugs
Anthony Markham

Abstract

Teprotumumab (teprotumumab-trbw; TEPEZZA™ - Horizon Therapeutics) is a monoclonal antibody insulin-like growth factor-I receptor (IGF-IR) antagonist developed for the treatment of thyroid eye disease (Graves ophthalmopathy/orbitopathy, thyroid-associated ophthalmopathy). Based on positive results from two multinational clinical trials teprotumumab was recently approved for this indication in the US. This article summarizes the milestones in the development of teprotumumab leading to this first approval for thyroid eye disease.

References

May 4, 2017·The New England Journal of Medicine·Terry J SmithRaymond S Douglas
Jan 24, 2020·The New England Journal of Medicine·Raymond S DouglasTerry J Smith

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Citations

Jul 9, 2020·Thyroid Research·Michelle Ting, Daniel G Ezra
Feb 3, 2021·European Journal of Ophthalmology·Catherine J HwangJulian D Perry
Jan 5, 2021·Frontiers in Endocrinology·Terry J Smith
Oct 19, 2020·Medicina clínica·Andrés González-García, Marco Sales-Sanz
Feb 22, 2021·European Journal of Medicinal Chemistry·Shuo YuanBin Yu
Mar 21, 2021·International Ophthalmology Clinics·Christopher J Hwang, Kian Eftekhari
Jun 22, 2021·Frontiers in Endocrinology·Terry J Smith
Jul 11, 2021·Eye·Shoaib UgradarRaymond S Douglas
Aug 22, 2021·Journal of Endocrinological Investigation·E J Neag, T J Smith
Sep 23, 2021·Plastic and Reconstructive Surgery. Global Open·Shoaib UgradarRaymond S Douglas
Nov 10, 2021·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Julia KangKimberly Cockerham

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