PMID: 9639875Jun 26, 1998Paper

TER94, a Drosophila homolog of the membrane fusion protein CDC48/p97, is accumulated in nonproliferating cells: in the reproductive organs and in the brain of the imago

Insect Biochemistry and Molecular Biology
M PintérP Friedrich

Abstract

We have cloned a Drosophila homolog of the membrane fusion protein CDC48/p97. The open reading frame of the Drosophila homolog encodes an 801 amino acid long protein (TER94), which shows high similarity to the known CDC48/p97 sequences. The chromosomal position of TER94 is 46 C/D. TER94 is expressed in embryo, in pupae and in imago, but is suppressed in larva. In the imago, the immunoreactivity was exclusively present in the head and in the gonads of both sexes. In the head the most striking staining was observed in the entire neuropil of the mushroom body and in the antennal glomeruli. Besides TER94, sex-specific forms were also detected in the gonads of the imago: p47 in the ovaries and p98 in the testis. TER94/p47 staining was observed in the nurse cells and often in the oöcytes, while TER94/p98 staining was present in the sperm bundles. On the basis of its distribution we suggest that TER94 functions in the protein transport utilizing endoplasmic reticulum and Golgi derived vesicles.

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Citations

Mar 3, 2005·Journal of Molecular Biology·Byron DeLaBarre, Axel T Brunger
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·C LavoieJ J Bergeron
Aug 22, 2001·Molecular Biology of the Cell·V KondylisC Rabouille
Feb 5, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Masatoshi Esaki, Teru Ogura
May 17, 2006·Biochemical and Biophysical Research Communications·Seiji YamauchiTeru Ogura
Apr 20, 2006·Journal of Structural Biology·Valerie E PyePaul S Freemont
Apr 24, 2002·Developmental Biology·Jonathan C DunneCatherine Rabouille
May 23, 2006·Molecular Cell·Byron DeLaBarreAxel T Brunger
Jan 24, 2007·Biochemical and Biophysical Research Communications·J M M MüllerD T Shima
Aug 9, 2016·Journal of Cardiovascular Development and Disease·Meera C ViswanathanAnthony Cammarato
Feb 25, 2009·The Journal of Cell Biology·Michelle A AveryMarc R Freeman
Feb 23, 2002·Cell Death and Differentiation·H HigashiyamaA Kakizuka
Jul 7, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Damdinsuren BoldbaatarKozo Fujisaki
Feb 11, 2009·Journal of Proteome Research·Liudy GarciaMarcelo Valle de Sousa

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