Teratogenic actions of ethanol in the mouse: a minireview

Pharmacology, Biochemistry, and Behavior
H C BeckerC L Randall

Abstract

The deleterious effects of prenatal ethanol exposure have been extensively documented in clinical and experimental studies. This paper provides an overview of work conducted with mice to examine the myriad of adverse consequences that result from embryonic/fetal exposure to ethanol. All of the hallmark features of the clinical fetal alcohol syndrome have been demonstrated in mice, including prenatal and postnatal growth retardation, structural malformations and behavioral abnormalities associated with central nervous system dysfunction. As expected, the severity and profile of effects is related to both dosage level and timing of exposure. In addition, these effects have been demonstrated following acute and chronic exposure, with a variety of routes of administration employed. Furthermore, a number of strains have been used in these studies and the variant response (susceptibility) to the teratogenic actions of ethanol exhibited among different mouse strains support the notion that genetic factors govern, at least in part, vulnerability to these effects of ethanol. More recent studies using mouse models have focused on examining potential mechanisms underlying the full spectrum of ethanol's teratogenic actions.

References

Mar 1, 1979·Early Human Development·J Dobbing, J Sands
Jul 1, 1977·Alcoholism, Clinical and Experimental Research·C L RandallD W Walker
Jun 1, 1979·Teratology·C L Randall, W J Taylor
Jun 1, 1977·Teratology·G F Chernoff
Apr 1, 1976·American Journal of Obstetrics and Gynecology·J B Kronick
Oct 1, 1992·Teratology·L E KotchK K Sulik
Aug 1, 1992·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L E Kotch, K K Sulik
Sep 1, 1992·Neurotoxicology and Teratology·L D Middaugh, G D Gentry
Jul 1, 1992·Developmental Psychobiology·D M Gilliam, L E Kotch
Mar 20, 1992·Brain Research. Developmental Brain Research·H C ScottP K Rudeen
May 1, 1992·Annals of Plastic Surgery·H Becker
Dec 1, 1991·Alcoholism, Clinical and Experimental Research·L D Middaugh, W O Boggan
Aug 1, 1991·Alcoholism, Clinical and Experimental Research·C L RandallR F Anton
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·U B SchambraK K Sulik
Dec 1, 1990·Alcoholism, Clinical and Experimental Research·C L RandallR F Anton
Apr 1, 1990·Teratology·E F ZimmermanM D Collins
May 1, 1990·Neurotoxicology and Teratology·C D DriscollE P Riley
Aug 1, 1990·Alcoholism, Clinical and Experimental Research·D M Gilliam, K T Irtenkauf
Oct 1, 1990·Alcoholism, Clinical and Experimental Research·S SchenkerG I Henderson
Oct 1, 1990·Alcoholism, Clinical and Experimental Research·E P Riley
Oct 1, 1990·Alcoholism, Clinical and Experimental Research·J R WestJ P Brandt
Jan 1, 1990·Annals of Medicine·J R West, C R Goodlett
Apr 1, 1989·Alcoholism, Clinical and Experimental Research·W O BogganL D Middaugh
Aug 1, 1989·Alcoholism, Clinical and Experimental Research·S J Ewald
Oct 1, 1989·Alcoholism, Clinical and Experimental Research·D M GilliamE P Riley
Jan 1, 1989·Annals of the New York Academy of Sciences·C L RandallN M White
Jan 1, 1989·Annals of the New York Academy of Sciences·C V Vorhees
Jun 1, 1988·Alcoholism, Clinical and Experimental Research·L D Middaugh, K L Ayers
Jun 1, 1988·Alcoholism, Clinical and Experimental Research·C L RandallH C Becker

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Citations

Feb 19, 2011·Cell Biology and Toxicology·Elisa CebralMarta Dolores Mudry
May 24, 2005·Reproductive Toxicology·Anne R GreenleeMichael D Mercieca
Oct 2, 2002·Brain Research. Developmental Brain Research·Shu-Huei HsiaoGerald D Frye
Apr 16, 2003·Brain Research. Developmental Brain Research·Shu-Huei Hsiao, Gerald D Frye
Jul 31, 2003·Brain Research. Developmental Brain Research·Feng C ZhouTing-Kai Li
Nov 24, 1999·Brain Research. Developmental Brain Research·T A McIntyreI A Shibley
Nov 30, 2002·Alcohol·Michael W Hartl, Ivan A Shibley
Jan 19, 2012·International Journal of Epidemiology·Anne-Marie Nybo AndersenKatrine Strandberg-Larsen
May 7, 2013·Annual Review of Neuroscience·Anita V Devineni, Ulrike Heberlein
Feb 10, 2011·Disease Models & Mechanisms·Kimberly D McClureUlrike Heberlein
Nov 15, 2013·Neurotoxicology and Teratology·Samantha MahabirRobert Gerlai
Aug 4, 2009·Neurotoxicology·Edward D LevinAnnette Kirshner
Dec 23, 2008·Neurotoxicology·Cristiane do Socorro Ferraz MaiaVania Maria Moraes Ferreira
Dec 11, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Sonja A RasmussenDanielle S Ross
Feb 21, 2009·Paediatric and Perinatal Epidemiology·Eric A MillerUNKNOWN National Birth Defects Prevention Study
Jul 9, 2010·Alcoholism, Clinical and Experimental Research·Jennifer A HippShay Soker
Jun 15, 2010·Birth Defects Research. Part C, Embryo Today : Reviews·Peter G Alexander, Rocky S Tuan
Mar 16, 2013·Alcoholism, Clinical and Experimental Research·Kylee J VeazeyMichael C Golding
Mar 18, 2011·Alcoholism, Clinical and Experimental Research·Yuanyuan ChenFeng C Zhou
Nov 5, 2005·Alcoholism, Clinical and Experimental Research·Robert C Ristuccia, Linda P Spear
Mar 24, 2009·Alcoholism, Clinical and Experimental Research·Peter CoyleAllan M Rofe
Feb 3, 2009·Alcoholism, Clinical and Experimental Research·Yohaan Fernandes, Robert Gerlai
Sep 22, 2009·Alcoholism, Clinical and Experimental Research·Alla ArzumnayanEmanuel Rubin
Sep 30, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Nina Kaminen-AholaSuyinn Chong
Jun 3, 2016·Alcoholism, Clinical and Experimental Research·Emilie R LundeJayanth Ramadoss
Jun 15, 2016·Birth Defects Research. Part A, Clinical and Molecular Teratology·Kersti K Linask, Mingda Han
Sep 29, 2004·Neurotoxicology and Teratology·Michael J CarvanFrederick E Williams
Sep 15, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·C LovelyJohann Eberhart
May 22, 2009·Biology of Reproduction·Philip C Haycock

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