PMID: 20650088Jun 1, 1995Paper

Teratogenic effects of retinoic acid and related substances on the early development of the zebrafish (Brachydanio rerio) as assessed by a novel scoring system

Toxicology in Vitro : an International Journal Published in Association with BIBRA
K Herrmann

Abstract

The early development of the zebrafish Brachydanio rerio is shown to be suitable as a test system for prescreening drugs suspected to be hazardous to humans. The teratogenic effects of all-trans-retinoic acid (tretinoin) and eight chemically related substances, such as 3,4-didehydro-retinol (vitamin A(2)), 4-oxo-retinoic acid and several cis isomers, are analysed. Zebrafish development offers several advantages as a test system: large amounts of eggs can be collected throughout the year. Because the embryo is translucent, organ development can be monitored in vivo. After 1 day, eyes, heart and blood circulation is visible already, and the development is synchronous up to day 3 after fertilization. The effects of the retinoids can be scored easily, and the substances can be ranked and be compared by their effectiveness. Further, a new scoring method is presented which also allows comparison of the relative strength of the teratogenic effects of the substances on the various organs enabling investigation of the structure-activity relationship. Concentrations of 10(-19)-10(-6)M all-trans-retinoic acid generate malformations such as oedema, brain deformities (anophthalmy, microcephaly and acephaly), duplication of the otic placodes...Continue Reading

References

Aug 1, 1978·Epilepsia·G E Slater, D Johnston
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N YangR M Evans
Dec 17, 1987·Nature·V GiguereR M Evans
Apr 28, 1988·Nature·N BrandA Dejean
Jun 1, 1984·The Journal of Experimental Zoology·M Baumann, K Sander
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S Berking
Jan 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K Herrmann

❮ Previous
Next ❯

Citations

Feb 24, 2006·Archives of Toxicology·Thomas WoehrmannUlrich Hübel
May 31, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiaoqin WuJianying Hu
Sep 12, 2001·General and Comparative Endocrinology·M SammarE Lubzens
Aug 12, 2014·Aquatic Toxicology·Adam JonasKlara Hilscherova
Nov 13, 2013·Future Medicinal Chemistry·Bhaskar C DasTodd Evans
Jun 21, 2012·Environmental Toxicology and Chemistry·Wei ZhangJiang Zhu
Oct 15, 2013·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jessica A PalmerFred R Kirchner
Apr 27, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Eva OliveiraBenjamin Piña
Jan 1, 2013·Green Chemistry : an International Journal and Green Chemistry Resource : GC·T T SchugJ P Myers
Sep 13, 2016·International Journal of Molecular Sciences·Tonya R Ellis, Bryan D Crawford
Oct 30, 2016·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Anaïs BoglinoManuel Manchado
May 2, 2001·The Journal of Comparative Neurology·O BricaudA Ghysen
Oct 6, 2005·Journal of Neuroscience Research·Chuan-Jiang Yu, Lei Li
Dec 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rosario ReyesJudith S Eisen
May 17, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yan GaoLei Li
Jan 12, 2012·Developmental Neurobiology·Sebastien Côté, Pierre Drapeau
Jun 6, 2006·Journal of Morphology·Matthew J McHenry, George V Lauder
May 4, 2006·Cell Motility and the Cytoskeleton·Michael J ReddPaul Martin
Sep 15, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Serguei ParinovAlexander Emelyanov
Jun 8, 2018·Environmental Science and Pollution Research International·Hongzhou YaoChao Xu
Apr 15, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alicia E NovakAngeles B Ribera
May 25, 2006·Journal of Neuroscience Research·Luoxiu Huang, Lei Li
Jul 11, 2006·Journal of Molecular Evolution·Alicia E NovakAngeles B Ribera
Aug 19, 2007·Journal of Morphology·G N RobertsonF M Smith
Nov 18, 2018·International Journal of Legal Medicine·Camille RichevalYvan Gaillard
Jan 8, 2014·Environmental Toxicology and Chemistry·Yujiang WangQiaoxiang Dong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.