PMID: 6539735Jun 1, 1984Paper

Teratological study of Fischer rats fed diet containing added vomitoxin

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
R E Morrissey

Abstract

Vomitoxin (deoxynivalenol), a tricothecene mycotoxin produced by Fusarium species, has been detected in corn, wheat and other cereal grains intended for consumption by man and by animals used for food. The teratogenic potential of vomitoxin administered in the diet was studied by feeding a vomitoxin-containing certified rat feed ad lib. to groups of Fischer 344 rats during the entire course of pregnancy. The vomitoxin was added to the diet at a level of 0.0, 0.5, 2.0 or 5.0 ppm. There were no overt signs of toxicity in the dams, and no statistically significant differences in feed consumption at any level compared to the control group. Dams in the two groups receiving the highest levels of vomitoxin tended to weigh less at term than other females, and after removal of the pups and uterus their carcass weights were significantly lower than those in the control group. Term foetuses were examined by standard teratological techniques. Male and female pup weights were unaffected by the maternal treatment. Vomitoxin had no statistically significant adverse effects on the incidence of gross, skeletal or visceral abnormalities. Neither dams nor pups showed any significant histopathological changes.

References

Oct 1, 1973·Computers in Biology and Medicine·W G HarlessG E Miller
Oct 1, 1982·Bulletin of Environmental Contamination and Toxicology·K S KheraT Kuiper-Goodman

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Citations

Sep 1, 1986·Mycotoxin Research·Y ItoY Ueno
Jun 1, 1987·Pharmacology, Biochemistry, and Behavior·D E ClarkM S Lerma
Nov 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R E MorrisseyR F Vesonder
May 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K S KheraG Angers
Sep 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D L ArnoldR F Vesonder
Jan 1, 1988·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K S Khera, C Whalen
Mar 15, 2005·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·James J Pestka, Alexa T Smolinski
Sep 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K NishieJ W Dorner
Dec 6, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Thomas F X CollinsDennis I Ruggles
Sep 11, 2017·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Lutz Edler
Jan 4, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Madelyn C HuangDori Germolec
May 1, 1985·Applied and Environmental Microbiology·R E Morrissey, R F Vesonder

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